CFLAR
Summary: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603599 Ensembl IDEnsembl:ENSG00000003402 HGNC IDHGNC:HGNC:1876 PHARMGKB IDPA26425 Map Location2q33.1 | |||||
GO terms in CFLAR
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0002020 | protease binding |
| MF | IEA | GO:0005123 | death receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008047 | enzyme activator activity |
| MF | IEA | GO:0016504 | peptidase activator activity |
| MF | IEA | GO:0044877 | protein-containing complex binding |
Gene expression in normal tissue: CFLAR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CFLAR
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-140534 | via Death Receptors in the presence of ligand |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-3371378 | Regulation by c-FLIP |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD12 | Bicalutamide | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CFLAR
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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