CFLAR
Summary: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CASP8 and FADD like apoptosis regulator | MIM:603599 | Ensembl:ENSG00000003402 | HGNC:HGNC:1876 | PA26425 | 2q33.1 |
GO terms in CFLAR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0002020 | protease binding |
| MF | IEA | GO:0005123 | death receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008047 | enzyme activator activity |
| MF | IEA | GO:0016504 | peptidase activator activity |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IBA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | ISS | GO:0007519 | skeletal muscle tissue development |
| BP | IEA | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| BP | IEA | GO:0010952 | positive regulation of peptidase activity |
| BP | IEA | GO:0010976 | positive regulation of neuron projection development |
| BP | ISS | GO:0014732 | skeletal muscle atrophy |
| BP | ISS | GO:0014842 | regulation of skeletal muscle satellite cell proliferation |
| BP | ISS | GO:0014866 | skeletal myofibril assembly |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0033574 | response to testosterone |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | ISS | GO:0043403 | skeletal muscle tissue regeneration |
| BP | ISS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0060544 | regulation of necroptotic process |
| BP | IEA | GO:0060546 | negative regulation of necroptotic process |
| BP | IEA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IEA | GO:0071392 | cellular response to estradiol stimulus |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | IEA | GO:0071732 | cellular response to nitric oxide |
| BP | IEA | GO:0072126 | positive regulation of glomerular mesangial cell proliferation |
| BP | ISS | GO:1901740 | negative regulation of myoblast fusion |
| BP | TAS | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IBA | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IDA | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IMP | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | TAS | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:1903055 | positive regulation of extracellular matrix organization |
| BP | IEA | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process |
| BP | IEA | GO:1903845 | negative regulation of cellular response to transforming growth factor beta stimulus |
| BP | IEA | GO:1903944 | negative regulation of hepatocyte apoptotic process |
| BP | IEA | GO:2000347 | positive regulation of hepatocyte proliferation |
| BP | IDA | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0031264 | death-inducing signaling complex |
| CC | IEA | GO:0031265 | CD95 death-inducing signaling complex |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IDA | GO:0097342 | ripoptosome |
Gene expression in normal tissue: CFLAR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CFLAR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-140534 | via Death Receptors in the presence of ligand |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-3371378 | Regulation by c-FLIP |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5218900 | CASP8 activity is inhibited |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-69416 | Dimerization of procaspase-8 |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75158 | TRAIL signaling |
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | trail_pathway | TRAIL signaling pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2507 | Nanomaterial induced apoptosis |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CFLAR
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.