ST3GAL5
Summary: Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604402 Ensembl IDEnsembl:ENSG00000115525 HGNC IDHGNC:HGNC:10872 PHARMGKB IDPA35773 Map Location2p11.2 | |||||
GO terms in ST3GAL5
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
| MF | TAS | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
| MF | TAS | GO:0004513 | neolactotetraosylceramide alpha-2,3-sialyltransferase activity |
| MF | TAS | GO:0008373 | sialyltransferase activity |
| MF | IBA | GO:0047291 | lactosylceramide alpha-2,3-sialyltransferase activity |
| MF | IDA | GO:0047291 | lactosylceramide alpha-2,3-sialyltransferase activity |
Gene expression in normal tissue: ST3GAL5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ST3GAL5
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00604 | Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human) |
| wikipathways | WP1423 | Ganglio Sphingolipid Metabolism |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085001 | Sialic acid metabolism |
| reactome | R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ST3GAL5
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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