ST3GAL5
Summary: Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | MIM:604402 | Ensembl:ENSG00000115525 | HGNC:HGNC:10872 | PA35773 | 2p11.2 |
GO terms in ST3GAL5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
| MF | TAS | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
| MF | TAS | GO:0004513 | neolactotetraosylceramide alpha-2,3-sialyltransferase activity |
| MF | TAS | GO:0008373 | sialyltransferase activity |
| MF | IBA | GO:0047291 | lactosylceramide alpha-2,3-sialyltransferase activity |
| MF | IDA | GO:0047291 | lactosylceramide alpha-2,3-sialyltransferase activity |
| BP | NAS | GO:0001574 | ganglioside biosynthetic process |
| BP | TAS | GO:0005975 | carbohydrate metabolic process |
| BP | TAS | GO:0006688 | glycosphingolipid biosynthetic process |
| BP | IEA | GO:0097503 | sialylation |
| CC | NAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: ST3GAL5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ST3GAL5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00604 | Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human) |
| wikipathways | WP1423 | Ganglio Sphingolipid Metabolism |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085001 | Sialic acid metabolism |
| reactome | R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ST3GAL5
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.