ST3GAL5


Summary: Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ST3 beta-galactoside alpha-2,3-sialyltransferase 5MIM:604402Ensembl:ENSG00000115525HGNC:HGNC:10872PA357732p11.2

GO terms in ST3GAL5


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
MFTASGO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
MFTASGO:0004513neolactotetraosylceramide alpha-2,3-sialyltransferase activity
MFTASGO:0008373sialyltransferase activity
MFIBAGO:0047291lactosylceramide alpha-2,3-sialyltransferase activity
MFIDAGO:0047291lactosylceramide alpha-2,3-sialyltransferase activity
BPNASGO:0001574ganglioside biosynthetic process
BPTASGO:0005975carbohydrate metabolic process
BPTASGO:0006688glycosphingolipid biosynthetic process
BPIEAGO:0097503sialylation
CCNASGO:0000139Golgi membrane
CCTASGO:0000139Golgi membrane
CCTASGO:0005887integral component of plasma membrane
CCTASGO:0016021integral component of membrane

Gene expression in normal tissue: ST3GAL5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ST3GAL5


DatabasePathway IDPathway Des.
kegghsa00604Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human)
wikipathwaysWP1423Ganglio Sphingolipid Metabolism
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4085001Sialic acid metabolism
reactomeR-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-446219Synthesis of substrates in N-glycan biosythesis
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ST3GAL5

​​​​