CCKBR
Summary: This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:118445 Ensembl IDEnsembl:ENSG00000110148 HGNC IDHGNC:HGNC:1571 PHARMGKB IDPA26143 Map Location11p15.4 | |||||
GO terms in CCKBR
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001696 | gastric acid secretion |
| BP | NAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | TAS | GO:0008283 | cell proliferation |
Gene expression in normal tissue: CCKBR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCKBR
Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00225 | Esomeprazole Action Pathway |
| smpdb | SMP00226 | Omeprazole Action Pathway |
| smpdb | SMP00227 | Lansoprazole Action Pathway |
| smpdb | SMP00228 | Pantoprazole Action Pathway |
| smpdb | SMP00229 | Rabeprazole Action Pathway |
| smpdb | SMP00230 | Ranitidine Action Pathway |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCKBR
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.