Summary: This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015].

cholecystokinin B receptorMIM:118445Ensembl:ENSG00000110148HGNC:HGNC:1571PA2614311p15.4

GO terms in CCKBR

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001696gastric acid secretion
BPNASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway
BPIDAGO:0007204positive regulation of cytosolic calcium ion concentration
BPTASGO:0008283cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPIDAGO:0038188cholecystokinin signaling pathway
BPIEAGO:0043551regulation of phosphatidylinositol 3-kinase activity
BPIEAGO:0048565digestive tract development
BPIEAGO:0048732gland development
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
MFIDAGO:0004951cholecystokinin receptor activity
MFIPIGO:0005515protein binding
MFIDAGO:0015054gastrin receptor activity
MFIPIGO:0017046peptide hormone binding
MFIDAGO:0031741type B gastrin/cholecystokinin receptor binding
MFTASGO:00469351-phosphatidylinositol-3-kinase regulator activity

Gene expression in normal tissue: CCKBR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCKBR

DatabasePathway IDPathway Des.
smpdbSMP00225Esomeprazole Action Pathway
smpdbSMP00226Omeprazole Action Pathway
smpdbSMP00227Lansoprazole Action Pathway
smpdbSMP00228Pantoprazole Action Pathway
smpdbSMP00229Rabeprazole Action Pathway
smpdbSMP00230Ranitidine Action Pathway
smpdbSMP00231Famotidine Action Pathway
smpdbSMP00232Cimetidine Action Pathway
smpdbSMP00233Nizatidine Action Pathway
smpdbSMP00246Pirenzepine Action Pathway
smpdbSMP00589Gastric Acid Production
smpdbSMP00734Roxatidine acetate Action Pathway
smpdbSMP00735Metiamide Action Pathway
smpdbSMP00736Betazole Action Pathway
wikipathwaysWP117GPCRs, Other
wikipathwaysWP24Peptide GPCRs
wikipathwaysWP2597Secretion of Hydrochloric Acid in Parietal Cells
wikipathwaysWP3679Cell-type Dependent Selectivity of CCK2R Signaling
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPK

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCKBR