IER3


Summary: This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
immediate early response 3MIM:602996Ensembl:ENSG00000137331HGNC:HGNC:5392PA296396p21.33

GO terms in IER3


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005829cytosol
CCIEAGO:0016021integral component of membrane
BPTASGO:0006915apoptotic process
BPTASGO:0009653anatomical structure morphogenesis
BPTASGO:0014066regulation of phosphatidylinositol 3-kinase signaling
BPIEAGO:0043066negative regulation of apoptotic process
BPIBAGO:2001020regulation of response to DNA damage stimulus
BPIMPGO:2001020regulation of response to DNA damage stimulus

Gene expression in normal tissue: IER3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IER3


DatabasePathway IDPathway Des.
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IER3

​​​​