IER3
Summary: This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| immediate early response 3 | MIM:602996 | Ensembl:ENSG00000137331 | HGNC:HGNC:5392 | PA29639 | 6p21.33 |
GO terms in IER3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | TAS | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:2001020 | regulation of response to DNA damage stimulus |
| BP | IMP | GO:2001020 | regulation of response to DNA damage stimulus |
Gene expression in normal tissue: IER3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IER3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IER3
CLASSFICATION
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