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SPHK1

Summary: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
sphingosine kinase 1	MIM:603730	Ensembl:ENSG00000176170	HGNC:HGNC:11240	PA36070	17q25.1

Gene Categories:

KINASE TUMOR SUPPRESSOR DRUGGABLE GENOME G PROTEIN COUPLED RECEPTOR LIPID KINASE

GO terms in SPHK1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0000287	magnesium ion binding
MF	ISS	GO:0000287	magnesium ion binding
MF	IDA	GO:0003677	DNA binding
MF	IEA	GO:0003951	NAD+ kinase activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005516	calmodulin binding
MF	IDA	GO:0005524	ATP binding
MF	IDA	GO:0008481	sphinganine kinase activity
MF	TAS	GO:0008481	sphinganine kinase activity
MF	IDA	GO:0017050	D-erythro-sphingosine kinase activity
MF	TAS	GO:0017050	D-erythro-sphingosine kinase activity
MF	IMP	GO:0038036	sphingosine-1-phosphate receptor activity
MF	IPI	GO:0051721	protein phosphatase 2A binding
CC	IEA	GO:0005634	nucleus
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
BP	IEA	GO:0001568	blood vessel development
BP	IEA	GO:0003376	sphingosine-1-phosphate signaling pathway
BP	TAS	GO:0006457	protein folding
BP	IDA	GO:0006670	sphingosine metabolic process
BP	IEA	GO:0006954	inflammatory response
BP	TAS	GO:0007165	signal transduction
BP	IEA	GO:0007420	brain development
BP	IMP	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
BP	IDA	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
BP	IDA	GO:0019722	calcium-mediated signaling
BP	TAS	GO:0030148	sphingolipid biosynthetic process
BP	IDA	GO:0030307	positive regulation of cell growth
BP	IDA	GO:0030335	positive regulation of cell migration
BP	IDA	GO:0031398	positive regulation of protein ubiquitination
BP	IEA	GO:0032651	regulation of interleukin-1 beta production
BP	TAS	GO:0035556	intracellular signal transduction
BP	IDA	GO:0043066	negative regulation of apoptotic process
BP	TAS	GO:0043066	negative regulation of apoptotic process
BP	IDA	GO:0045766	positive regulation of angiogenesis
BP	IDA	GO:0045931	positive regulation of mitotic cell cycle
BP	IDA	GO:0045987	positive regulation of smooth muscle contraction
BP	IGI	GO:0046512	sphingosine biosynthetic process
BP	IMP	GO:0046512	sphingosine biosynthetic process
BP	NAS	GO:0046521	sphingoid catabolic process
BP	IEA	GO:0046834	lipid phosphorylation
BP	IDA	GO:0048146	positive regulation of fibroblast proliferation
BP	IMP	GO:0051092	positive regulation of NF-kappaB transcription factor activity
BP	IMP	GO:1901224	positive regulation of NIK/NF-kappaB signaling

Gene expression in normal tissue: SPHK1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPHK1

Database	Pathway ID	Pathway Des.
netpath	Pathway_Fibroblast__growth__factor-1	Fibroblast growth factor-1
pid	fcer1pathway	Fc-epsilon receptor I signaling in mast cells
pid	integrin3_pathway	Beta3 integrin cell surface interactions
pid	pdgfrbpathway	PDGFR-beta signaling pathway
pid	s1p_meta_pathway	Sphingosine 1-phosphate (S1P) pathway
pid	s1p_s1p1_pathway	S1P1 pathway
kegg	hsa00600	Sphingolipid metabolism - Homo sapiens (human)
kegg	hsa04020	Calcium signaling pathway - Homo sapiens (human)
kegg	hsa04071	Sphingolipid signaling pathway - Homo sapiens (human)
kegg	hsa04072	Phospholipase D signaling pathway - Homo sapiens (human)
kegg	hsa04370	VEGF signaling pathway - Homo sapiens (human)
kegg	hsa04371	Apelin signaling pathway - Homo sapiens (human)
kegg	hsa04666	Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegg	hsa05152	Tuberculosis - Homo sapiens (human)
humancyc	PWY3DJ-11470	sphingosine and sphingosine-1-phosphate metabolism
wikipathways	WP1422	Sphingolipid Metabolism
wikipathways	WP26	Signal Transduction of S1P Receptor
wikipathways	WP4142	Metabolism of Spingolipids in ER and Golgi apparatus
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1660661	Sphingolipid de novo biosynthesis
reactome	R-HSA-194138	Signaling by VEGF
reactome	R-HSA-390466	Chaperonin-mediated protein folding
reactome	R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis
reactome	R-HSA-391251	Protein folding
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-428157	Sphingolipid metabolism
reactome	R-HSA-4420097	VEGFA-VEGFR2 Pathway
reactome	R-HSA-5218921	VEGFR2 mediated cell proliferation
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
biocarta	edg1pathway	phospholipids as signalling intermediaries

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	2
iGMDRD68	Paclitaxel	2
iGMDRD353	PD0325901	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPHK1

SITE

DATATYPES

CLASSFICATION

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