SPHK1


Summary: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:603730
PHARMGKB IDPA36070
Map Location17q25.1

GO terms in SPHK1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000287 magnesium ion binding
MF ISS GO:0000287 magnesium ion binding
MF IDA GO:0003677 DNA binding
MF IEA GO:0003951 NAD+ kinase activity
MF IPI GO:0005515 protein binding
MF IDA GO:0005516 calmodulin binding
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Gene expression in normal tissue: SPHK1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 6

Gene-drug pathway distribution

ERK MAPK signaling1Metabolic pathways1Protein stability and degradation1

Pathways in SPHK1


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Database
Pathway ID
Pathway Des.
netpath Pathway_Fibroblast__growth__factor-1 Fibroblast growth factor-1
pid fcer1pathway Fc-epsilon receptor I signaling in mast cells
pid integrin3_pathway Beta3 integrin cell surface interactions
pid pdgfrbpathway PDGFR-beta signaling pathway
pid s1p_meta_pathway Sphingosine 1-phosphate (S1P) pathway
pid s1p_s1p1_pathway S1P1 pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 2
iGMDRD68 Paclitaxel 2
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPHK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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