SPHK1
Summary: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603730 Ensembl IDEnsembl:ENSG00000176170 HGNC IDHGNC:HGNC:11240 PHARMGKB IDPA36070 Map Location17q25.1 | |||||
GO terms in SPHK1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003951 | NAD+ kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005516 | calmodulin binding |
Gene expression in normal tissue: SPHK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPHK1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | integrin3_pathway | Beta3 integrin cell surface interactions |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | s1p_meta_pathway | Sphingosine 1-phosphate (S1P) pathway |
| pid | s1p_s1p1_pathway | S1P1 pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPHK1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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