TIMELESS
Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| timeless circadian regulator | MIM:603887 | Ensembl:ENSG00000111602 | HGNC:HGNC:11813 | PA36520 | 12q13.3 |
Gene Categories:
DNA REPAIRGO terms in TIMELESS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000076 | DNA replication checkpoint |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0002009 | morphogenesis of an epithelium |
| BP | IBA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | ISS | GO:0006974 | cellular response to DNA damage stimulus |
| BP | ISS | GO:0007623 | circadian rhythm |
| BP | TAS | GO:0009582 | detection of abiotic stimulus |
| BP | IEA | GO:0030324 | lung development |
| BP | IMP | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0042752 | regulation of circadian rhythm |
| BP | IBA | GO:0043111 | replication fork arrest |
| BP | IMP | GO:0044770 | cell cycle phase transition |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IBA | GO:0048478 | replication fork protection |
| BP | IEA | GO:0048754 | branching morphogenesis of an epithelial tube |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0072711 | cellular response to hydroxyurea |
| BP | IMP | GO:0072719 | cellular response to cisplatin |
| BP | IMP | GO:1904976 | cellular response to bleomycin |
| BP | IMP | GO:2000781 | positive regulation of double-strand break repair |
| CC | IBA | GO:0000228 | nuclear chromosome |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IC | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0031298 | replication fork protection complex |
| MF | IBA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: TIMELESS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TIMELESS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-73894 | DNA Repair |
| pid | atr_pathway | ATR signaling pathway |
| pid | circadianpathway | Circadian rhythm pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TIMELESS
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