BSN
Summary: Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| bassoon presynaptic cytomatrix protein | MIM:604020 | Ensembl:ENSG00000164061 | HGNC:HGNC:1117 | PA25434 | 3p21.31 |
Gene Categories:
CELL SURFACEGO terms in BSN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0046872 | metal ion binding |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IEA | GO:0007416 | synapse assembly |
| BP | IEA | GO:0035418 | protein localization to synapse |
| BP | IEA | GO:0099526 | presynapse to nucleus signaling pathway |
| CC | TAS | GO:0005634 | nucleus |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IEA | GO:0044306 | neuron projection terminus |
| CC | ISS | GO:0048786 | presynaptic active zone |
| CC | ISS | GO:0048788 | cytoskeleton of presynaptic active zone |
| CC | TAS | GO:0048788 | cytoskeleton of presynaptic active zone |
| CC | ISS | GO:0060076 | excitatory synapse |
Gene expression in normal tissue: BSN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BSN
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BSN
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