WASF1


Summary: The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
WAS protein family member 1MIM:605035Ensembl:ENSG00000112290HGNC:HGNC:12732PA373436q21

GO terms in WASF1


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005741mitochondrial outer membrane
CCTASGO:0005856cytoskeleton
CCIEAGO:0005925focal adhesion
CCTASGO:0015629actin cytoskeleton
CCIEAGO:0030027lamellipodium
CCIMPGO:0031209SCAR complex
CCIDAGO:0032991protein-containing complex
CCIEAGO:0045202synapse
BPISSGO:0006898receptor-mediated endocytosis
BPIMPGO:0016601Rac protein signal transduction
BPTASGO:0030041actin filament polymerization
BPIEAGO:0051388positive regulation of neurotrophin TRK receptor signaling pathway
BPNASGO:0065003protein-containing complex assembly
BPIEAGO:0072673lamellipodium morphogenesis
BPIEAGO:0097484dendrite extension
BPISSGO:1990416cellular response to brain-derived neurotrophic factor stimulus
BPIMPGO:2000601positive regulation of Arp2/3 complex-mediated actin nucleation
MFIEAGO:0003779actin binding
MFIPIGO:0005515protein binding
MFIMPGO:0044877protein-containing complex binding
MFIMPGO:0048365Rac GTPase binding
MFIPIGO:0051018protein kinase A binding

Gene expression in normal tissue: WASF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WASF1


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEs
reactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEs
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartarac1pathwayrac1 cell motility signaling pathway
biocartasalmonellapathwayhow does salmonella hijack a cell
pide2f_pathwayE2F transcription factor network
pidrac1_pathwayRAC1 signaling pathway
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WASF1

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