CDK5R2
Summary: The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 5 regulatory subunit 2 | MIM:603764 | Ensembl:ENSG00000171450 | HGNC:HGNC:1776 | PA26312 | 2q35 |
GO terms in CDK5R2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0003779 | actin binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | ISS | GO:0016534 | cyclin-dependent protein kinase 5 activator activity |
| MF | TAS | GO:0016534 | cyclin-dependent protein kinase 5 activator activity |
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0021549 | cerebellum development |
| BP | IEA | GO:0021722 | superior olivary nucleus maturation |
| BP | IEA | GO:0021766 | hippocampus development |
| BP | IEA | GO:0021819 | layer formation in cerebral cortex |
| BP | IEA | GO:0045956 | positive regulation of calcium ion-dependent exocytosis |
| BP | IEA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0016020 | membrane |
| CC | IEA | GO:0016533 | protein kinase 5 complex |
| CC | ISS | GO:0030426 | growth cone |
| CC | ISS | GO:0043005 | neuron projection |
Gene expression in normal tissue: CDK5R2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK5R2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | lis1pathway | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK5R2
CLASSFICATION
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