CDK5R2
Summary: The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603764 Ensembl IDEnsembl:ENSG00000171450 HGNC IDHGNC:HGNC:1776 PHARMGKB IDPA26312 Map Location2q35 | |||||
GO terms in CDK5R2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0003779 | actin binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | ISS | GO:0016534 | cyclin-dependent protein kinase 5 activator activity |
| MF | TAS | GO:0016534 | cyclin-dependent protein kinase 5 activator activity |
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IEA | GO:0001764 | neuron migration |
Gene expression in normal tissue: CDK5R2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK5R2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | lis1pathway | Lissencephaly gene (LIS1) in neuronal migration and development |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK5R2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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