KYNU
Summary: Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namekynureninase OMIM IDMIM:605197 Ensembl IDEnsembl:ENSG00000115919 HGNC IDHGNC:HGNC:6469 PHARMGKB IDPA30258 Map Location2q22.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in KYNU
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0006569 | tryptophan catabolic process |
| BP | TAS | GO:0006569 | tryptophan catabolic process |
| BP | IEA | GO:0009435 | NAD biosynthetic process |
| BP | IMP | GO:0009435 | NAD biosynthetic process |
| BP | IBA | GO:0019441 | tryptophan catabolic process to kynurenine |
| BP | IEA | GO:0019442 | tryptophan catabolic process to acetyl-CoA |
Gene expression in normal tissue: KYNU
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KYNU
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00063 | Tryptophan Metabolism |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP2485 | NAD Biosynthesis II (from tryptophan) |
| wikipathways | WP465 | Tryptophan metabolism |
| humancyc | NADSYN-PWY | NAD de novo biosynthesis |
| humancyc | PWY-5651 | tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KYNU
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.