ABCC10
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612509 Ensembl IDEnsembl:ENSG00000124574 HGNC IDHGNC:HGNC:52 PHARMGKB IDPA24392 Map Location6p21.1 | |||||
GO terms in ABCC10
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | TAS | GO:0043225 | ATPase-coupled anion transmembrane transporter activity |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0016020 | membrane |
Gene expression in normal tissue: ABCC10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCC10
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00436 | Vinblastine Action Pathway |
| smpdb | SMP00437 | Vincristine Action Pathway |
| smpdb | SMP00438 | Vindesine Action Pathway |
| smpdb | SMP00439 | Vinorelbine Action Pathway |
| smpdb | SMP00642 | Nevirapine Metabolism Pathway |
| pharmgkb | PA150981002 | Vinka Alkaloid Pathway, Pharmacokinetics |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCC10
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.