ABCC10
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATP binding cassette subfamily C member 10 | MIM:612509 | Ensembl:ENSG00000124574 | HGNC:HGNC:52 | PA24392 | 6p21.1 |
GO terms in ABCC10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | TAS | GO:0043225 | ATPase-coupled anion transmembrane transporter activity |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0016020 | membrane |
| BP | IBA | GO:0055085 | transmembrane transport |
| BP | TAS | GO:0055085 | transmembrane transport |
| BP | IEA | GO:0099133 | ATP hydrolysis coupled anion transmembrane transport |
Gene expression in normal tissue: ABCC10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCC10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00436 | Vinblastine Action Pathway |
| smpdb | SMP00437 | Vincristine Action Pathway |
| smpdb | SMP00438 | Vindesine Action Pathway |
| smpdb | SMP00439 | Vinorelbine Action Pathway |
| smpdb | SMP00642 | Nevirapine Metabolism Pathway |
| pharmgkb | PA150981002 | Vinka Alkaloid Pathway, Pharmacokinetics |
| pharmgkb | PA155028030 | Tenofovir/Adefovir Pathway, Pharmacokinetics |
| pharmgkb | PA165950411 | Nevirapine Pathway, Pharmacokinetics |
| kegg | hsa02010 | ABC transporters - Homo sapiens (human) |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382556 | ABC-family proteins mediated transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCC10
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.