ABCC10


Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in ABCC10


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0005524 ATP binding
MF IBA GO:0042626 ATPase activity, coupled to transmembrane movement of substances
MF TAS GO:0043225 ATPase-coupled anion transmembrane transporter activity
CC HDA GO:0005765 lysosomal membrane
CC TAS GO:0005886 plasma membrane
CC IBA GO:0016020 membrane
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Gene expression in normal tissue: ABCC10

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 1

Gene-drug pathway distribution

Metabolic pathways1

Pathways in ABCC10


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Database
Pathway ID
Pathway Des.
smpdb SMP00436 Vinblastine Action Pathway
smpdb SMP00437 Vincristine Action Pathway
smpdb SMP00438 Vindesine Action Pathway
smpdb SMP00439 Vinorelbine Action Pathway
smpdb SMP00642 Nevirapine Metabolism Pathway
pharmgkb PA150981002 Vinka Alkaloid Pathway, Pharmacokinetics
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABCC10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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