Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010].

ATP binding cassette subfamily C member 10MIM:612509Ensembl:ENSG00000124574HGNC:HGNC:52PA243926p21.1

GO terms in ABCC10

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005524ATP binding
MFIBAGO:0042626ATPase activity, coupled to transmembrane movement of substances
MFTASGO:0043225ATPase-coupled anion transmembrane transporter activity
CCHDAGO:0005765lysosomal membrane
CCTASGO:0005886plasma membrane
BPIBAGO:0055085transmembrane transport
BPTASGO:0055085transmembrane transport
BPIEAGO:0099133ATP hydrolysis coupled anion transmembrane transport

Gene expression in normal tissue: ABCC10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ABCC10

DatabasePathway IDPathway Des.
smpdbSMP00436Vinblastine Action Pathway
smpdbSMP00437Vincristine Action Pathway
smpdbSMP00438Vindesine Action Pathway
smpdbSMP00439Vinorelbine Action Pathway
smpdbSMP00642Nevirapine Metabolism Pathway
pharmgkbPA150981002Vinka Alkaloid Pathway, Pharmacokinetics
pharmgkbPA155028030Tenofovir/Adefovir Pathway, Pharmacokinetics
pharmgkbPA165950411Nevirapine Pathway, Pharmacokinetics
kegghsa02010ABC transporters - Homo sapiens (human)
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-382556ABC-family proteins mediated transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABCC10