PLOD3
Summary: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603066 Ensembl IDEnsembl:ENSG00000106397 HGNC IDHGNC:HGNC:9083 PHARMGKB IDPA33413 Map Location7q22.1 | |||||
GO terms in PLOD3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005506 | iron ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008475 | procollagen-lysine 5-dioxygenase activity |
| MF | IDA | GO:0008475 | procollagen-lysine 5-dioxygenase activity |
| MF | IMP | GO:0008475 | procollagen-lysine 5-dioxygenase activity |
| MF | TAS | GO:0008475 | procollagen-lysine 5-dioxygenase activity |
Gene expression in normal tissue: PLOD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLOD3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
| kegg | hsa00514 | Other types of O-glycan biosynthesis - Homo sapiens (human) |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-1650814 | Collagen biosynthesis and modifying enzymes |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLOD3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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