PLOD3


Summary: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
procollagen-lysine,2-oxoglutarate 5-dioxygenase 3MIM:603066Ensembl:ENSG00000106397HGNC:HGNC:9083PA334137q22.1

GO terms in PLOD3


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005506iron ion binding
MFIPIGO:0005515protein binding
MFIBAGO:0008475procollagen-lysine 5-dioxygenase activity
MFIDAGO:0008475procollagen-lysine 5-dioxygenase activity
MFIMPGO:0008475procollagen-lysine 5-dioxygenase activity
MFTASGO:0008475procollagen-lysine 5-dioxygenase activity
MFIEAGO:0031418L-ascorbic acid binding
MFIMPGO:0033823procollagen glucosyltransferase activity
MFTASGO:0033823procollagen glucosyltransferase activity
MFTASGO:0050211procollagen galactosyltransferase activity
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005794Golgi apparatus
CCIEAGO:0005802trans-Golgi network
CCIEAGO:0030867rough endoplasmic reticulum membrane
CCIEAGO:0031012extracellular matrix
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001886endothelial cell morphogenesis
BPIMPGO:0006493protein O-linked glycosylation
BPIEAGO:0008104protein localization
BPIBAGO:0017185peptidyl-lysine hydroxylation
BPIDAGO:0017185peptidyl-lysine hydroxylation
BPIMPGO:0017185peptidyl-lysine hydroxylation
BPIEAGO:0021915neural tube development
BPIBAGO:0030199collagen fibril organization
BPIEAGO:0030199collagen fibril organization
BPIEAGO:0032870cellular response to hormone stimulus
BPIBAGO:0032963collagen metabolic process
BPIEAGO:0032963collagen metabolic process
BPIEAGO:0042311vasodilation
BPIBAGO:0046947hydroxylysine biosynthetic process
BPIDAGO:0046947hydroxylysine biosynthetic process
BPIMPGO:0046947hydroxylysine biosynthetic process
BPIEAGO:0048730epidermis morphogenesis
BPIEAGO:0055114oxidation-reduction process
BPIEAGO:0060425lung morphogenesis
BPIEAGO:0070831basement membrane assembly

Gene expression in normal tissue: PLOD3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLOD3


DatabasePathway IDPathway Des.
kegghsa00310Lysine degradation - Homo sapiens (human)
kegghsa00514Other types of O-glycan biosynthesis - Homo sapiens (human)
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474290Collagen formation
reactomeR-HSA-1650814Collagen biosynthesis and modifying enzymes

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLOD3

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