UNC5A

Summary: UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameunc-5 netrin receptor A
OMIM IDMIM:607869
Ensembl IDEnsembl:ENSG00000113763
HGNC IDHGNC:HGNC:12567
PHARMGKB IDPA37204
Map Location5q35.2

GO terms in UNC5A


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IEA GO:0016021 integral component of membrane
CC ISS GO:0031226 intrinsic component of plasma membrane
CC ISS GO:0032589 neuron projection membrane
CC ISS GO:0032809 neuronal cell body membrane
CC IEA GO:0045121 membrane raft
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Gene expression in normal tissue: UNC5A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Protein stability and degradation1

Pathways in UNC5A


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109581 Apoptosis
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-373752 Netrin-1 signaling
reactome R-HSA-373752 Netrin-1 signaling
reactome R-HSA-418886 Netrin mediated repulsion signals
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UNC5A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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