UNC5A
Summary: UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| unc-5 netrin receptor A | MIM:607869 | Ensembl:ENSG00000113763 | HGNC:HGNC:12567 | PA37204 | 5q35.2 |
GO terms in UNC5A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0031226 | intrinsic component of plasma membrane |
| CC | ISS | GO:0032589 | neuron projection membrane |
| CC | ISS | GO:0032809 | neuronal cell body membrane |
| CC | IEA | GO:0045121 | membrane raft |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007411 | axon guidance |
| BP | ISS | GO:0031175 | neuron projection development |
| BP | IEA | GO:0033564 | anterior/posterior axon guidance |
| BP | ISS | GO:0038007 | netrin-activated signaling pathway |
| MF | IEA | GO:0005042 | netrin receptor activity |
Gene expression in normal tissue: UNC5A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UNC5A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-418886 | Netrin mediated repulsion signals |
| reactome | R-HSA-418889 | via Dependence Receptors in the absence of ligand |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| pid | netrin_pathway | Netrin-mediated signaling events |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UNC5A
CLASSFICATION
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