NAT8
Summary: This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606716 Ensembl IDEnsembl:ENSG00000144035 HGNC IDHGNC:HGNC:18069 PHARMGKB IDPA31450 Map Location2p13.1 | |||||
Gene Categories:
DRUG RESISTANCEGO terms in NAT8
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor |
| MF | TAS | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0047198 | cysteine-S-conjugate N-acetyltransferase activity |
| BP | IDA | GO:0006749 | glutathione metabolic process |
| BP | IEA | GO:0006749 | glutathione metabolic process |
Gene expression in normal tissue: NAT8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NAT8
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-977225 | Amyloid fiber formation |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NAT8
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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