RPL14
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ribosomal protein L14 | MIM:617414 | Ensembl:ENSG00000188846 | HGNC:HGNC:10305 | PA34673 | 3p22.1 |
GO terms in RPL14
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | HDA | GO:0003723 | RNA binding |
MF | NAS | GO:0003735 | structural constituent of ribosome |
MF | IPI | GO:0005515 | protein binding |
MF | HDA | GO:0045296 | cadherin binding |
BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
BP | IMP | GO:0006364 | rRNA processing |
BP | NAS | GO:0006412 | translation |
BP | TAS | GO:0006413 | translational initiation |
BP | TAS | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
BP | IBA | GO:0042273 | ribosomal large subunit biogenesis |
BP | IMP | GO:0042273 | ribosomal large subunit biogenesis |
CC | TAS | GO:0005829 | cytosol |
CC | HDA | GO:0016020 | membrane |
CC | HDA | GO:0022625 | cytosolic large ribosomal subunit |
CC | IBA | GO:0022625 | cytosolic large ribosomal subunit |
CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: RPL14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPL14
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa03010 | Ribosome - Homo sapiens (human) |
wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
reactome | R-HSA-156902 | Peptide chain elongation |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-168254 | Influenza Infection |
reactome | R-HSA-168255 | Influenza Life Cycle |
reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
reactome | R-HSA-192823 | Viral mRNA Translation |
reactome | R-HSA-2408522 | Selenoamino acid metabolism |
reactome | R-HSA-2408557 | Selenocysteine synthesis |
reactome | R-HSA-376176 | Signaling by ROBO receptors |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-422475 | Axon guidance |
reactome | R-HSA-5663205 | Infectious disease |
reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
reactome | R-HSA-72312 | rRNA processing |
reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
reactome | R-HSA-72764 | Eukaryotic Translation Termination |
reactome | R-HSA-72766 | Translation |
reactome | R-HSA-72766 | Translation |
reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
reactome | R-HSA-8953854 | Metabolism of RNA |
reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in RPL14