SYT7


Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
synaptotagmin 7MIM:604146Ensembl:ENSG00000011347HGNC:HGNC:11514PA3629511q12.2

GO terms in SYT7


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001786phosphatidylserine binding
MFIBAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFISSGO:0005516calmodulin binding
MFIBAGO:0005544calcium-dependent phospholipid binding
MFISSGO:0005544calcium-dependent phospholipid binding
MFNASGO:0005544calcium-dependent phospholipid binding
MFISSGO:0005546phosphatidylinositol-4,5-bisphosphate binding
MFIBAGO:0019905syntaxin binding
MFIBAGO:0030276clathrin binding
CCISSGO:0005764lysosome
CCIEAGO:0005765lysosomal membrane
CCISSGO:0005777peroxisome
CCIEAGO:0005778peroxisomal membrane
CCIEAGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCISSGO:0008021synaptic vesicle
CCIEAGO:0016021integral component of membrane
CCIEAGO:0030054cell junction
CCIEAGO:0030425dendrite
CCIEAGO:0030670phagocytic vesicle membrane
CCIEAGO:0030672synaptic vesicle membrane
CCIEAGO:0031045dense core granule
CCISSGO:0032009early phagosome
CCIEAGO:0042734presynaptic membrane
CCIEAGO:0043025neuronal cell body
CCIEAGO:0043679axon terminus
CCHDAGO:0070062extracellular exosome
BPISSGO:0001778plasma membrane repair
BPIBAGO:0006906vesicle fusion
BPISSGO:0006909phagocytosis
BPIEAGO:0014059regulation of dopamine secretion
BPIBAGO:0016079synaptic vesicle exocytosis
BPIBAGO:0017158regulation of calcium ion-dependent exocytosis
BPISSGO:0036465synaptic vesicle recycling
BPIEAGO:0045956positive regulation of calcium ion-dependent exocytosis
BPISSGO:0046850regulation of bone remodeling
BPIBAGO:0048791calcium ion-regulated exocytosis of neurotransmitter
BPISSGO:0048791calcium ion-regulated exocytosis of neurotransmitter
BPISSGO:0050764regulation of phagocytosis
BPISSGO:0050796regulation of insulin secretion
BPISSGO:0070092regulation of glucagon secretion
BPISSGO:0090119vesicle-mediated cholesterol transport
BPISSGO:0090385phagosome-lysosome fusion
BPISSGO:1990926short-term synaptic potentiation
BPISSGO:1990927calcium ion regulated lysosome exocytosis

Gene expression in normal tissue: SYT7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SYT7


DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794362Protein-protein interactions at synapses

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SYT7

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