FMNL3
Summary: The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| formin like 3 | MIM:616288 | Ensembl:ENSG00000161791 | HGNC:HGNC:23698 | PA134992328 | 12q13.12 |
GO terms in FMNL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IMP | GO:0007010 | cytoskeleton organization |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | IMP | GO:0016477 | cell migration |
| BP | IEA | GO:0030036 | actin cytoskeleton organization |
| MF | IEA | GO:0003779 | actin binding |
| MF | IEA | GO:0017048 | Rho GTPase binding |
| MF | ISS | GO:0032794 | GTPase activating protein binding |
Gene expression in normal tissue: FMNL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FMNL3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FMNL3
CLASSFICATION
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