LATS1
Summary: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| large tumor suppressor kinase 1 | MIM:603473 | Ensembl:ENSG00000131023 | HGNC:HGNC:6514 | PA30301 | 6q25.1 |
GO terms in LATS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0030331 | estrogen receptor binding |
| BP | IBA | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IDA | GO:0000819 | sister chromatid segregation |
| BP | IEA | GO:0001827 | inner cell mass cell fate commitment |
| BP | IEA | GO:0001828 | inner cell mass cellular morphogenesis |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0009755 | hormone-mediated signaling pathway |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0030216 | keratinocyte differentiation |
| BP | IDA | GO:0030833 | regulation of actin filament polymerization |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IMP | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway |
| BP | IEA | GO:0034613 | cellular protein localization |
| BP | IBA | GO:0035329 | hippo signaling |
| BP | IDA | GO:0035329 | hippo signaling |
| BP | TAS | GO:0035329 | hippo signaling |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043254 | regulation of protein complex assembly |
| BP | IDA | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0046620 | regulation of organ growth |
| BP | IMP | GO:0051220 | cytoplasmic sequestering of protein |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0060644 | mammary gland epithelial cell differentiation |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process |
| CC | IBA | GO:0000922 | spindle pole |
| CC | IDA | GO:0000922 | spindle pole |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: LATS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LATS1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04392 | Hippo signaling pathway - multiple species - Homo sapiens (human) |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2028269 | Signaling by Hippo |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD270 | Ciclosporin | 4 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD6 | AM-580 | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 9 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD366 | PI-103 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LATS1
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.