CCNB2
Summary: Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecyclin B2 OMIM IDMIM:602755 Ensembl IDEnsembl:ENSG00000157456 HGNC IDHGNC:HGNC:1580 PHARMGKB IDPA26148 Map Location15q22.2 | |||||
GO terms in CCNB2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
Gene expression in normal tissue: CCNB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCNB2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1859 | Mitotic G2-G2-M phases |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP707 | DNA Damage Response |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCNB2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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