SYNGR1
Summary: This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| synaptogyrin 1 | MIM:603925 | Ensembl:ENSG00000100321 | HGNC:HGNC:11498 | PA36280 | 22q13.1 |
GO terms in SYNGR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| BP | IEA | GO:0006605 | protein targeting |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | ISS | GO:0045055 | regulated exocytosis |
| BP | ISS | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| BP | ISS | GO:0048172 | regulation of short-term neuronal synaptic plasticity |
| BP | ISS | GO:0048499 | synaptic vesicle membrane organization |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0030672 | synaptic vesicle membrane |
| CC | IBA | GO:0031594 | neuromuscular junction |
| CC | TAS | GO:0035577 | azurophil granule membrane |
| CC | IEA | GO:0042470 | melanosome |
Gene expression in normal tissue: SYNGR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SYNGR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SYNGR1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.