CD247
Summary: The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameCD247 molecule OMIM IDMIM:186780 Ensembl IDEnsembl:ENSG00000198821 HGNC IDHGNC:HGNC:1677 PHARMGKB IDPA26219 Map Location1q24.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in CD247
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0042101 | T cell receptor complex |
| CC | IDA | GO:0042101 | T cell receptor complex |
Gene expression in normal tissue: CD247
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD247
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| netpath | Pathway_TCR | TCR |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD247
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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