TIFA
Summary: This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TRAF interacting protein with forkhead associated domain | MIM:609028 | Ensembl:ENSG00000145365 | HGNC:HGNC:19075 | PA162405777 | 4q25 |
GO terms in TIFA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005622 | intracellular |
| BP | IEA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: TIFA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TIFA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP3656 | Interleukin-1 Induced Activation of NF-kappa-B |
| wikipathways | WP3877 | Simplified Depiction of MYD88 Distinct Input-Output Pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TIFA
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