NAPRT
Summary: Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nicotinate phosphoribosyltransferase | MIM:611552 | Ensembl:ENSG00000147813 | HGNC:HGNC:30450 | PA142671293 | 8q24.3 |
GO terms in NAPRT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| MF | IBA | GO:0004516 | nicotinate phosphoribosyltransferase activity |
| MF | IDA | GO:0004516 | nicotinate phosphoribosyltransferase activity |
| MF | TAS | GO:0004516 | nicotinate phosphoribosyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | IMP | GO:0006979 | response to oxidative stress |
| BP | IBA | GO:0009435 | NAD biosynthetic process |
| BP | IEA | GO:0019358 | nicotinate nucleotide salvage |
| BP | IBA | GO:0034355 | NAD salvage |
| BP | TAS | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: NAPRT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NAPRT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-196807 | Nicotinate metabolism |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-197264 | Nicotinamide salvaging |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| kegg | hsa00760 | Nicotinate and nicotinamide metabolism - Homo sapiens (human) |
| wikipathways | WP3645 | NAD+ biosynthetic pathways |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NAPRT
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.