NAPRT
Summary: Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:611552 Ensembl IDEnsembl:ENSG00000147813 HGNC IDHGNC:HGNC:30450 PHARMGKB IDPA142671293 Map Location8q24.3 | |||||
GO terms in NAPRT
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| MF | IBA | GO:0004516 | nicotinate phosphoribosyltransferase activity |
| MF | IDA | GO:0004516 | nicotinate phosphoribosyltransferase activity |
| MF | TAS | GO:0004516 | nicotinate phosphoribosyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | IMP | GO:0006979 | response to oxidative stress |
Gene expression in normal tissue: NAPRT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NAPRT
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-196807 | Nicotinate metabolism |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD756 | GNE-617 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NAPRT
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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