KLF4


Summary: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602253
PHARMGKB IDPA30138
Map Location9q31.2

GO terms in KLF4


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0000790 nuclear chromatin
CC IBA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IEA GO:0005719 nuclear euchromatin
CC IEA GO:0005737 cytoplasm
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Gene expression in normal tissue: KLF4

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Protein stability and degradation1

Pathways in KLF4


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Database
Pathway ID
Pathway Des.
wikipathways WP1991 SRF and miRs in Smooth Muscle Differentiation and Proliferation
wikipathways WP2023 Cell Differentiation - Index expanded
wikipathways WP2857 Mesodermal Commitment Pathway
wikipathways WP2877 Vitamin D Receptor Pathway
wikipathways WP3299 let-7 inhibition of ES cell reprogramming
wikipathways WP3527 Preimplantation Embryo
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLF4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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