KLF4
Summary: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:602253 Ensembl IDEnsembl:ENSG00000136826 HGNC IDHGNC:HGNC:6348 PHARMGKB IDPA30138 Map Location9q31.2 |
GO terms in KLF4
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0000790 | nuclear chromatin |
CC | IBA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IEA | GO:0005719 | nuclear euchromatin |
CC | IEA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: KLF4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLF4
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1991 | SRF and miRs in Smooth Muscle Differentiation and Proliferation |
wikipathways | WP2023 | Cell Differentiation - Index expanded |
wikipathways | WP2857 | Mesodermal Commitment Pathway |
wikipathways | WP2877 | Vitamin D Receptor Pathway |
wikipathways | WP3299 | let-7 inhibition of ES cell reprogramming |
wikipathways | WP3527 | Preimplantation Embryo |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in KLF4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |