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KLF4

Summary: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Kruppel like factor 4	MIM:602253	Ensembl:ENSG00000136826	HGNC:HGNC:6348	PA30138	9q31.2

Gene Categories:

CLINICALLY ACTIONABLE RNA DIRECTED DNA POLYMERASE TRANSCRIPTION FACTOR COMPLEX KINASE TRANSCRIPTION FACTOR BINDING PROTEASE LIPID KINASE

GO terms in KLF4

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0000790	nuclear chromatin
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IEA	GO:0005719	nuclear euchromatin
CC	IEA	GO:0005737	cytoplasm
CC	IEA	GO:0044798	nuclear transcription factor complex
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IBA	GO:0006357	regulation of transcription by RNA polymerase II
BP	ISS	GO:0006366	transcription by RNA polymerase II
BP	TAS	GO:0007500	mesodermal cell fate determination
BP	TAS	GO:0008285	negative regulation of cell proliferation
BP	IEA	GO:0009913	epidermal cell differentiation
BP	IGI	GO:0010628	positive regulation of gene expression
BP	IGI	GO:0010629	negative regulation of gene expression
BP	IEA	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
BP	IEA	GO:0014740	negative regulation of muscle hyperplasia
BP	IDA	GO:0016525	negative regulation of angiogenesis
BP	ISS	GO:0019827	stem cell population maintenance
BP	IEA	GO:0031077	post-embryonic camera-type eye development
BP	IDA	GO:0032088	negative regulation of NF-kappaB transcription factor activity
BP	IMP	GO:0032270	positive regulation of cellular protein metabolic process
BP	IDA	GO:0034115	negative regulation of heterotypic cell-cell adhesion
BP	TAS	GO:0035019	somatic stem cell population maintenance
BP	IMP	GO:0035166	post-embryonic hemopoiesis
BP	IDA	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BP	IEA	GO:0043551	regulation of phosphatidylinositol 3-kinase activity
BP	IDA	GO:0045415	negative regulation of interleukin-8 biosynthetic process
BP	IMP	GO:0045429	positive regulation of nitric oxide biosynthetic process
BP	ISS	GO:0045444	fat cell differentiation
BP	ISS	GO:0045595	regulation of cell differentiation
BP	IDA	GO:0045892	negative regulation of transcription, DNA-templated
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	ISS	GO:0045893	positive regulation of transcription, DNA-templated
BP	NAS	GO:0045893	positive regulation of transcription, DNA-templated
BP	IGI	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IMP	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	ISS	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IMP	GO:0046985	positive regulation of hemoglobin biosynthetic process
BP	IEA	GO:0048662	negative regulation of smooth muscle cell proliferation
BP	IEA	GO:0048679	regulation of axon regeneration
BP	IEA	GO:0048730	epidermis morphogenesis
BP	TAS	GO:0050728	negative regulation of inflammatory response
BP	IGI	GO:0051247	positive regulation of protein metabolic process
BP	IEA	GO:0051898	negative regulation of protein kinase B signaling
BP	IDA	GO:0051973	positive regulation of telomerase activity
BP	IEA	GO:0060070	canonical Wnt signaling pathway
BP	IDA	GO:0060761	negative regulation of response to cytokine stimulus
BP	IDA	GO:0061614	pri-miRNA transcription by RNA polymerase II
BP	IEA	GO:0070301	cellular response to hydrogen peroxide
BP	IEA	GO:0070373	negative regulation of ERK1 and ERK2 cascade
BP	IEA	GO:0071300	cellular response to retinoic acid
BP	IDA	GO:0071363	cellular response to growth factor stimulus
BP	IEA	GO:0071409	cellular response to cycloheximide
BP	IMP	GO:0071499	cellular response to laminar fluid shear stress
BP	IDA	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
BP	IEA	GO:1901653	cellular response to peptide
BP	IGI	GO:1903672	positive regulation of sprouting angiogenesis
BP	IEA	GO:1904798	positive regulation of core promoter binding
BP	IGI	GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell
BP	IEA	GO:1990830	cellular response to leukemia inhibitory factor
BP	IDA	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
BP	IDA	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production
MF	IEA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0000987	proximal promoter sequence-specific DNA binding
MF	ISS	GO:0001010	transcription factor activity, sequence-specific DNA-binding transcription factor recruiting
MF	IMP	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IPI	GO:0001085	RNA polymerase II transcription factor binding
MF	ISS	GO:0001085	RNA polymerase II transcription factor binding
MF	IDA	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding
MF	IEA	GO:0001221	transcription cofactor binding
MF	NAS	GO:0003700	DNA-binding transcription factor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008013	beta-catenin binding
MF	NAS	GO:0008270	zinc ion binding
MF	IEA	GO:0035014	phosphatidylinositol 3-kinase regulator activity
MF	IEA	GO:0042826	histone deacetylase binding
MF	ISS	GO:0044212	transcription regulatory region DNA binding
MF	IDA	GO:1990841	promoter-specific chromatin binding

Gene expression in normal tissue: KLF4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KLF4

Database	Pathway ID	Pathway Des.
wikipathways	WP1991	SRF and miRs in Smooth Muscle Differentiation and Proliferation
wikipathways	WP2023	Cell Differentiation - Index expanded
wikipathways	WP2857	Mesodermal Commitment Pathway
wikipathways	WP2877	Vitamin D Receptor Pathway
wikipathways	WP3299	let-7 inhibition of ES cell reprogramming
wikipathways	WP3527	Preimplantation Embryo
wikipathways	WP3946	White fat cell differentiation
wikipathways	WP3971	Role of Osx and miRNAs in tooth development
wikipathways	WP4149	White fat cell differentiation
pid	betacatenin_nuc_pathway	Regulation of nuclear beta catenin signaling and target gene transcription
kegg	hsa04550	Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-2980736	Peptide hormone metabolism
reactome	R-HSA-381340	Transcriptional regulation of white adipocyte differentiation
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin
reactome	R-HSA-452723	Transcriptional regulation of pluripotent stem cells

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLF4

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DATATYPES

CLASSFICATION

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