Summary: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].

Kruppel like factor 4MIM:602253Ensembl:ENSG00000136826HGNC:HGNC:6348PA301389q31.2

GO terms in KLF4

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000790nuclear chromatin
CCIEAGO:0005719nuclear euchromatin
CCIEAGO:0044798nuclear transcription factor complex
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPISSGO:0006366transcription by RNA polymerase II
BPTASGO:0007500mesodermal cell fate determination
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0009913epidermal cell differentiation
BPIGIGO:0010628positive regulation of gene expression
BPIGIGO:0010629negative regulation of gene expression
BPIEAGO:0014067negative regulation of phosphatidylinositol 3-kinase signaling
BPIEAGO:0014740negative regulation of muscle hyperplasia
BPIDAGO:0016525negative regulation of angiogenesis
BPISSGO:0019827stem cell population maintenance
BPIEAGO:0031077post-embryonic camera-type eye development
BPIDAGO:0032088negative regulation of NF-kappaB transcription factor activity
BPIMPGO:0032270positive regulation of cellular protein metabolic process
BPIDAGO:0034115negative regulation of heterotypic cell-cell adhesion
BPTASGO:0035019somatic stem cell population maintenance
BPIMPGO:0035166post-embryonic hemopoiesis
BPIDAGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0043551regulation of phosphatidylinositol 3-kinase activity
BPIDAGO:0045415negative regulation of interleukin-8 biosynthetic process
BPIMPGO:0045429positive regulation of nitric oxide biosynthetic process
BPISSGO:0045444fat cell differentiation
BPISSGO:0045595regulation of cell differentiation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0046985positive regulation of hemoglobin biosynthetic process
BPIEAGO:0048662negative regulation of smooth muscle cell proliferation
BPIEAGO:0048679regulation of axon regeneration
BPIEAGO:0048730epidermis morphogenesis
BPTASGO:0050728negative regulation of inflammatory response
BPIGIGO:0051247positive regulation of protein metabolic process
BPIEAGO:0051898negative regulation of protein kinase B signaling
BPIDAGO:0051973positive regulation of telomerase activity
BPIEAGO:0060070canonical Wnt signaling pathway
BPIDAGO:0060761negative regulation of response to cytokine stimulus
BPIDAGO:0061614pri-miRNA transcription by RNA polymerase II
BPIEAGO:0070301cellular response to hydrogen peroxide
BPIEAGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIEAGO:0071300cellular response to retinoic acid
BPIDAGO:0071363cellular response to growth factor stimulus
BPIEAGO:0071409cellular response to cycloheximide
BPIMPGO:0071499cellular response to laminar fluid shear stress
BPIDAGO:0090051negative regulation of cell migration involved in sprouting angiogenesis
BPIEAGO:1901653cellular response to peptide
BPIGIGO:1903672positive regulation of sprouting angiogenesis
BPIEAGO:1904798positive regulation of core promoter binding
BPIGIGO:1904998negative regulation of leukocyte adhesion to arterial endothelial cell
BPIEAGO:1990830cellular response to leukemia inhibitory factor
BPIDAGO:2000134negative regulation of G1/S transition of mitotic cell cycle
BPIDAGO:2000342negative regulation of chemokine (C-X-C motif) ligand 2 production
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0000987proximal promoter sequence-specific DNA binding
MFISSGO:0001010transcription factor activity, sequence-specific DNA-binding transcription factor recruiting
MFIMPGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0001085RNA polymerase II transcription factor binding
MFISSGO:0001085RNA polymerase II transcription factor binding
MFIDAGO:0001190transcriptional activator activity, RNA polymerase II transcription factor binding
MFIEAGO:0001221transcription cofactor binding
MFNASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008013beta-catenin binding
MFNASGO:0008270zinc ion binding
MFIEAGO:0035014phosphatidylinositol 3-kinase regulator activity
MFIEAGO:0042826histone deacetylase binding
MFISSGO:0044212transcription regulatory region DNA binding
MFIDAGO:1990841promoter-specific chromatin binding

Gene expression in normal tissue: KLF4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KLF4

DatabasePathway IDPathway Des.
wikipathwaysWP1991SRF and miRs in Smooth Muscle Differentiation and Proliferation
wikipathwaysWP2023Cell Differentiation - Index expanded
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3299let-7 inhibition of ES cell reprogramming
wikipathwaysWP3527Preimplantation Embryo
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP3971Role of Osx and miRNAs in tooth development
wikipathwaysWP4149White fat cell differentiation
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422085Synthesis, secretion, and deacylation of Ghrelin
reactomeR-HSA-452723Transcriptional regulation of pluripotent stem cells

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLF4