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TGM5

Summary: This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nametransglutaminase 5 OMIM IDMIM:603805 Ensembl IDEnsembl:ENSG00000104055 HGNC IDHGNC:HGNC:11781 PHARMGKB IDPA36494 Map Location15q15.2

Gene Categories:

DRUGGABLE GENOME

GO terms in TGM5

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0006464	cellular protein modification process
BP	TAS	GO:0008544	epidermis development
BP	IEA	GO:0018149	peptide cross-linking
BP	TAS	GO:0070268	cornification
CC	IEA	GO:0005737	cytoplasm
CC	TAS	GO:0005886	plasma membrane

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Gene expression in normal tissue: TGM5

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGM5

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-6805567	Keratinization
reactome	R-HSA-6809371	Formation of the cornified envelope

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGM5

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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