ARHGAP18

Summary: ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRho GTPase activating protein 18
OMIM IDMIM:613351
Ensembl IDEnsembl:ENSG00000146376
HGNC IDHGNC:HGNC:21035
PHARMGKB IDPA134884487
Map Location6q22.33

GO terms in ARHGAP18


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005096 GTPase activator activity
MF IMP GO:0005096 GTPase activator activity
MF TAS GO:0005096 GTPase activator activity
MF HDA GO:0045296 cadherin binding
BP IMP GO:0007264 small GTPase mediated signal transduction
BP IMP GO:0008360 regulation of cell shape
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Gene expression in normal tissue: ARHGAP18

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in ARHGAP18


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-194840 Rho GTPase cycle
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGAP18

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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