Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016].

neurexin 1MIM:600565Ensembl:ENSG00000179915HGNC:HGNC:8008PA317862p16.3

GO terms in NRXN1

Term TypeEvidence TypeGO Term IDGO Des.
CCISSGO:0005783endoplasmic reticulum
CCICGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCISSGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIDAGO:0009986cell surface
CCIEAGO:0030054cell junction
CCISSGO:0031965nuclear membrane
CCIEAGO:0032991protein-containing complex
CCISSGO:0042734presynaptic membrane
CCISSGO:0043025neuronal cell body
BPTASGO:0007158neuron cell-cell adhesion
BPIEAGO:0007165signal transduction
BPISSGO:0007268chemical synaptic transmission
BPISSGO:0007269neurotransmitter secretion
BPTASGO:0007411axon guidance
BPISSGO:0007416synapse assembly
BPIMPGO:0030534adult behavior
BPIMPGO:0035176social behavior
BPIMPGO:0042297vocal learning
BPIMPGO:0050885neuromuscular process controlling balance
BPISSGO:0050885neuromuscular process controlling balance
BPISSGO:0051965positive regulation of synapse assembly
BPISSGO:0051968positive regulation of synaptic transmission, glutamatergic
BPIEAGO:0060134prepulse inhibition
BPIEAGO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus
BPIMPGO:0071625vocalization behavior
BPISSGO:0090129positive regulation of synapse maturation
BPISSGO:0097104postsynaptic membrane assembly
BPISSGO:0097116gephyrin clustering involved in postsynaptic density assembly
BPISSGO:0097118neuroligin clustering involved in postsynaptic membrane assembly
BPISSGO:0097119postsynaptic density protein 95 clustering
BPIEAGO:0099560synaptic membrane adhesion
BPISSGO:2000463positive regulation of excitatory postsynaptic potential
BPIEAGO:2000821regulation of grooming behavior
MFISSGO:0005246calcium channel regulator activity
MFISSGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFISSGO:0033130acetylcholine receptor binding
MFTASGO:0038023signaling receptor activity
MFISSGO:0050839cell adhesion molecule binding
MFISSGO:0097109neuroligin family protein binding

Gene expression in normal tissue: NRXN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NRXN1

DatabasePathway IDPathway Des.
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-6794362Protein-protein interactions at synapses

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NRXN1