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ARHGAP12

Summary: This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameRho GTPase activating protein 12 OMIM IDMIM:610577 Ensembl IDEnsembl:ENSG00000165322 HGNC IDHGNC:HGNC:16348 PHARMGKB IDPA24957 Map Location10p11.22

GO terms in ARHGAP12

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0005096	GTPase activator activity
CC	IDA	GO:0001891	phagocytic cup
CC	IBA	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
BP	IMP	GO:0002011	morphogenesis of an epithelial sheet
BP	IMP	GO:0006911	phagocytosis, engulfment

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Gene expression in normal tissue: ARHGAP12

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARHGAP12

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-194840	Rho GTPase cycle

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGAP12

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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