TJP2


Summary: This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tight junction protein 2MIM:607709Ensembl:ENSG00000119139HGNC:HGNC:11828PA365339q21.11

Gene Categories:

KINASE

GO terms in TJP2


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004385guanylate kinase activity
MFIPIGO:0005515protein binding
MFIPIGO:0019904protein domain specific binding
MFIDAGO:0030674protein binding, bridging
MFHDAGO:0045296cadherin binding
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0005912adherens junction
CCIDAGO:0005923bicellular tight junction
CCIDAGO:0030054cell junction
BPTASGO:0035329hippo signaling
BPIEAGO:0046037GMP metabolic process
BPIEAGO:0046710GDP metabolic process
BPIMPGO:0050892intestinal absorption
BPIMPGO:0090557establishment of endothelial intestinal barrier
BPIMPGO:0090559regulation of membrane permeability

Gene expression in normal tissue: TJP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TJP2


DatabasePathway IDPathway Des.
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa05110Vibrio cholerae infection - Homo sapiens (human)
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
netpathPathway_EGFR1EGFR1
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-111465Apoptotic cleavage of cellular proteins
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2028269Signaling by Hippo
reactomeR-HSA-351906Apoptotic cleavage of cell adhesion proteins
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-75153Apoptotic execution phase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD792Cetuximab1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TJP2

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