ABCG2
Summary: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603756 Ensembl IDEnsembl:ENSG00000118777 HGNC IDHGNC:HGNC:74 PHARMGKB IDPA390 Map Location4q22.1 | |||||
GO terms in ABCG2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005215 | transporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0008559 | xenobiotic transmembrane transporting ATPase activity |
| MF | TAS | GO:0015232 | heme transporter activity |
| MF | IBA | GO:0015238 | drug transmembrane transporter activity |
Gene expression in normal tissue: ABCG2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCG2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA145011108 | Statin Pathway - Generalized, Pharmacokinetics |
| pharmgkb | PA145011110 | Pravastatin Pathway, Pharmacokinetics |
| pharmgkb | PA150642262 | Platinum Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA150653776 | Fluoropyrimidine Pathway, Pharmacokinetics |
| pharmgkb | PA152325160 | Gefitinib Pathway, Pharmacokinetics |
| pharmgkb | PA154426155 | Taxane Pathway, Pharmacokinetics |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCG2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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