Summary: The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

glutathione S-transferase omega 1MIM:605482Ensembl:ENSG00000148834HGNC:HGNC:13312PA13378705410q25.1

GO terms in GSTO1

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004364glutathione transferase activity
MFTASGO:0004364glutathione transferase activity
MFIPIGO:0005515protein binding
MFIDAGO:0016491oxidoreductase activity
MFIBAGO:0045174glutathione dehydrogenase (ascorbate) activity
MFIDAGO:0045174glutathione dehydrogenase (ascorbate) activity
MFTASGO:0050610methylarsonate reductase activity
CCHDAGO:0070062extracellular exosome
BPIDAGO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
BPICGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
BPICGO:0014810positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
BPIDAGO:0019852L-ascorbic acid metabolic process
BPTASGO:0035722interleukin-12-mediated signaling pathway
BPIDAGO:0042178xenobiotic catabolic process
BPIBAGO:0055114oxidation-reduction process
BPIEAGO:0055114oxidation-reduction process
BPIDAGO:0060315negative regulation of ryanodine-sensitive calcium-release channel activity
BPIDAGO:0060316positive regulation of ryanodine-sensitive calcium-release channel activity
BPIDAGO:0071243cellular response to arsenic-containing substance
BPIEAGO:0098869cellular oxidant detoxification
BPTASGO:1901687glutathione derivative biosynthetic process

Gene expression in normal tissue: GSTO1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GSTO1

DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-156580Phase II - Conjugation of compounds
reactomeR-HSA-156590Glutathione conjugation
reactomeR-HSA-168256Immune System
reactomeR-HSA-196836Vitamin C (ascorbate) metabolism
reactomeR-HSA-196849Metabolism of water-soluble vitamins and cofactors
reactomeR-HSA-196854Metabolism of vitamins and cofactors
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-447115Interleukin-12 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
reactomeR-HSA-9020591Interleukin-12 signaling
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP4100Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
wikipathwaysWP702Metapathway biotransformation Phase I and II
humancycPWY-4202arsenate detoxification I (glutaredoxin)
humancycPWY-6370ascorbate recycling (cytosolic)
kegghsa00480Glutathione metabolism - Homo sapiens (human)
kegghsa00980Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
kegghsa00982Drug metabolism - cytochrome P450 - Homo sapiens (human)
kegghsa00983Drug metabolism - other enzymes - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05204Chemical carcinogenesis - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GSTO1