GSTO1
Summary: The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:605482 Ensembl IDEnsembl:ENSG00000148834 HGNC IDHGNC:HGNC:13312 PHARMGKB IDPA133787054 Map Location10q25.1 | |||||
GO terms in GSTO1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004364 | glutathione transferase activity |
| MF | TAS | GO:0004364 | glutathione transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0016491 | oxidoreductase activity |
| MF | IBA | GO:0045174 | glutathione dehydrogenase (ascorbate) activity |
| MF | IDA | GO:0045174 | glutathione dehydrogenase (ascorbate) activity |
Gene expression in normal tissue: GSTO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GSTO1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156581 | Methylation |
| reactome | R-HSA-156590 | Glutathione conjugation |
| reactome | R-HSA-168256 | Immune System |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GSTO1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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