Summary: The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

CD34 moleculeMIM:142230Ensembl:ENSG00000174059HGNC:HGNC:1662PA262111q32.2

GO terms in CD34

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0008134transcription factor binding
MFIDAGO:0030246carbohydrate binding
MFIEAGO:0043199sulfate binding
BPIDAGO:0001894tissue homeostasis
BPIDAGO:0001935endothelial cell proliferation
BPIEPGO:0003094glomerular filtration
BPIEPGO:0003158endothelium development
BPIBAGO:0007160cell-matrix adhesion
BPIEPGO:0007165signal transduction
BPIDAGO:0008217regulation of blood pressure
BPISSGO:0008283cell proliferation
BPIEPGO:0010628positive regulation of gene expression
BPIMPGO:0010629negative regulation of gene expression
BPIDAGO:0030195negative regulation of blood coagulation
BPIDAGO:0032720negative regulation of tumor necrosis factor production
BPIDAGO:0032733positive regulation of interleukin-10 production
BPISSGO:0035759mesangial cell-matrix adhesion
BPIDAGO:0038001paracrine signaling
BPIDAGO:0042482positive regulation of odontogenesis
BPIDAGO:0045019negative regulation of nitric oxide biosynthetic process
BPIDAGO:0045766positive regulation of angiogenesis
BPIEPGO:0048870cell motility
BPTASGO:0050776regulation of immune response
BPISSGO:0050900leukocyte migration
BPIEPGO:0061042vascular wound healing
BPIMPGO:0071425hematopoietic stem cell proliferation
BPIDAGO:0071636positive regulation of transforming growth factor beta production
BPIDAGO:0071657positive regulation of granulocyte colony-stimulating factor production
BPIEPGO:0071657positive regulation of granulocyte colony-stimulating factor production
BPIDAGO:0071971extracellular exosome assembly
BPIEPGO:0072011glomerular endothelium development
BPIEPGO:0072089stem cell proliferation
BPIEPGO:0072254metanephric glomerular mesangial cell differentiation
BPIDAGO:0098609cell-cell adhesion
BPIDAGO:1900035negative regulation of cellular response to heat
BPIDAGO:1900038negative regulation of cellular response to hypoxia
BPIMPGO:1900041negative regulation of interleukin-2 secretion
BPIDAGO:1900168positive regulation of glial cell-derived neurotrophic factor secretion
BPIDAGO:1901215negative regulation of neuron death
BPIDAGO:2001214positive regulation of vasculogenesis
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCICGO:0009897external side of plasma membrane
CCIDAGO:0009897external side of plasma membrane
CCISSGO:0009925basal plasma membrane
CCISSGO:0016324apical plasma membrane
CCISSGO:0036053glomerular endothelium fenestra
CCIDAGO:0045171intercellular bridge
CCIDAGO:0048471perinuclear region of cytoplasm

Gene expression in normal tissue: CD34

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD34

DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
pidcmyb_pathwayC-MYB transcription factor network

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD34