CD34

Summary: The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameCD34 molecule
OMIM IDMIM:142230
Ensembl IDEnsembl:ENSG00000174059
HGNC IDHGNC:HGNC:1662
PHARMGKB IDPA26211
Map Location1q32.2

GO terms in CD34


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0008134 transcription factor binding
MF IDA GO:0030246 carbohydrate binding
MF IEA GO:0043199 sulfate binding
BP IDA GO:0001894 tissue homeostasis
BP IDA GO:0001935 endothelial cell proliferation
BP IEP GO:0003094 glomerular filtration
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Gene expression in normal tissue: CD34

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Protein stability and degradation1

Pathways in CD34


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
kegg hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegg hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
pid cmyb_pathway C-MYB transcription factor network
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD34

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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