GDF15


Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
growth differentiation factor 15MIM:605312Ensembl:ENSG00000130513HGNC:HGNC:30142PA13486664719p13.11

GO terms in GDF15


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005125cytokine activity
MFIBAGO:0005160transforming growth factor beta receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFIDAGO:0042803protein homodimerization activity
BPIDAGO:0000187activation of MAPK activity
BPIDAGO:0002023reduction of food intake in response to dietary excess
BPTASGO:0007165signal transduction
BPTASGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIBAGO:0030509BMP signaling pathway
BPIDAGO:0035860glial cell-derived neurotrophic factor receptor signaling pathway
BPISSGO:0040015negative regulation of multicellular organism growth
BPIBAGO:0042981regulation of apoptotic process
BPIBAGO:0043408regulation of MAPK cascade
BPIMPGO:0043410positive regulation of MAPK cascade
BPIBAGO:0048468cell development
BPIDAGO:0051897positive regulation of protein kinase B signaling
BPIMPGO:0051897positive regulation of protein kinase B signaling
BPIBAGO:0060395SMAD protein signal transduction
BPIDAGO:0060395SMAD protein signal transduction
BPISSGO:0060400negative regulation of growth hormone receptor signaling pathway
BPIEAGO:1901741positive regulation of myoblast fusion
CCIDAGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: GDF15

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GDF15


DatabasePathway IDPathway Des.
wikipathwaysWP4239EMT transition in Colorectal Cancer
pidp53downstreampathwayDirect p53 effectors
pidp73pathwayp73 transcription factor network
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GDF15

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