BCAR1


Summary: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BCAR1, Cas family scaffold proteinMIM:602941Ensembl:ENSG00000050820HGNC:HGNC:971PA2528116q23.1

GO terms in BCAR1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0001558regulation of cell growth
BPIDAGO:0007015actin filament organization
BPIEAGO:0007155cell adhesion
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPISSGO:0007173epidermal growth factor receptor signaling pathway
BPISSGO:0007186G-protein coupled receptor signaling pathway
BPNASGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0007229integrin-mediated signaling pathway
BPTASGO:0008283cell proliferation
BPISSGO:0008286insulin receptor signaling pathway
BPIDAGO:0010595positive regulation of endothelial cell migration
BPIBAGO:0016477cell migration
BPIDAGO:0016477cell migration
BPIDAGO:0030335positive regulation of cell migration
BPIMPGO:0035729cellular response to hepatocyte growth factor stimulus
BPTASGO:0042981regulation of apoptotic process
BPISSGO:0048008platelet-derived growth factor receptor signaling pathway
BPIMPGO:0048010vascular endothelial growth factor receptor signaling pathway
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPISSGO:0048011neurotrophin TRK receptor signaling pathway
BPIMPGO:0048012hepatocyte growth factor receptor signaling pathway
BPIDAGO:0050851antigen receptor-mediated signaling pathway
BPNASGO:0050852T cell receptor signaling pathway
BPIDAGO:0050853B cell receptor signaling pathway
BPNASGO:0051301cell division
BPIMPGO:0060326cell chemotaxis
BPIBAGO:0090527actin filament reorganization
CCIDAGO:0001726ruffle
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIBAGO:0005925focal adhesion
CCIDAGO:0005925focal adhesion
CCISSGO:0005925focal adhesion
CCIEAGO:0015629actin cytoskeleton
CCIEAGO:0030027lamellipodium
MFIPIGO:0005515protein binding
MFIEAGO:0017124SH3 domain binding
MFIPIGO:0019901protein kinase binding

Gene expression in normal tissue: BCAR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCAR1


DatabasePathway IDPathway Des.
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP306Focal Adhesion
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3967miR-509-3p alteration of YAP1-ECM axis
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidavb3_opn_pathwayOsteopontin-mediated events
pidcdc42_pathwayCDC42 signaling events
pidcxcr4_pathwayCXCR4-mediated signaling events
pidendothelinpathwayEndothelins
pidepha2_fwdpathwayEPHA2 forward signaling
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidigf1_pathwayIGF1 pathway
pidintegrin_a4b1_pathwayAlpha4 beta1 integrin signaling events
pidintegrin_a9b1_pathwayAlpha9 beta1 integrin signaling events
pidlysophospholipid_pathwayLPA receptor mediated events
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidnetrin_pathwayNetrin-mediated signaling events
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidprlsignalingeventspathwaySignaling events mediated by PRL
pidptp1bpathwaySignaling events mediated by PTP1B
pidrac1_pathwayRAC1 signaling pathway
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
pidupa_upar_pathwayUrokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
netpathPathway_BCRBCR
netpathPathway_EGFR1EGFR1
netpathPathway_GastrinGastrin
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartacell2cellpathwaycell to cell adhesion signaling
biocartaecmpathwayerk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocartaintegrinpathwayintegrin signaling pathway
biocartaptenpathwaypten dependent cell cycle arrest and apoptosis
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartavegfpathwayvegf hypoxia and angiogenesis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-354192Integrin alphaIIb beta3 signaling
reactomeR-HSA-372708p130Cas linkage to MAPK signaling for integrins
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76009Platelet Aggregation (Plug Formation)
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
reactomeR-HSA-9006921Integrin signaling
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD523Cyanoquinoline, 111
iGMDRD405PIK-751
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD341Triacsin c5
iGMDRD123Isoevodiamine3
iGMDRD137Indisulam5
iGMDRD481Dactolisib3
iGMDRD213SMR0000686502
iGMDRD705Nakiterpiosin2
iGMDRD6AM-5803
iGMDRD871BRD63682
iGMDRD286Nsc 6328395
iGMDRD872BRD71372
iGMDRD82Quiflapon2
iGMDRD886Compound 1541A2
iGMDRD263AACOCF33
iGMDRD579PF7502
iGMDRD772BRD47702
iGMDRD1008SR-II-138A3
iGMDRD126Tipifarnib2
iGMDRD151CHM-13
iGMDRD554CHEMBL14341372
iGMDRD427ABT7372
iGMDRD144NSC953972
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD193Fqi13
iGMDRD446LY 21832404
iGMDRD201SKI II2
iGMDRD260FQI-22
iGMDRD255SB2250022
iGMDRD474Avrainvillamide5
iGMDRD318PAC-15
iGMDRD52Rotenone2
iGMDRD888Compound 441
iGMDRD562Navitoclax2
iGMDRD188Piperlongumine5
iGMDRD100Zebularine2
iGMDRD74Idarubicin2
iGMDRD23Gossypol1
iGMDRD64Parbendazole3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCAR1

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