BCAR1
Summary: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCAR1, Cas family scaffold protein | MIM:602941 | Ensembl:ENSG00000050820 | HGNC:HGNC:971 | PA25281 | 16q23.1 |
GO terms in BCAR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001558 | regulation of cell growth |
| BP | IDA | GO:0007015 | actin filament organization |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | ISS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | ISS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | NAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | ISS | GO:0008286 | insulin receptor signaling pathway |
| BP | IDA | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IBA | GO:0016477 | cell migration |
| BP | IDA | GO:0016477 | cell migration |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | ISS | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | IMP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | ISS | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | IMP | GO:0048012 | hepatocyte growth factor receptor signaling pathway |
| BP | IDA | GO:0050851 | antigen receptor-mediated signaling pathway |
| BP | NAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IDA | GO:0050853 | B cell receptor signaling pathway |
| BP | NAS | GO:0051301 | cell division |
| BP | IMP | GO:0060326 | cell chemotaxis |
| BP | IBA | GO:0090527 | actin filament reorganization |
| CC | IDA | GO:0001726 | ruffle |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | ISS | GO:0005925 | focal adhesion |
| CC | IEA | GO:0015629 | actin cytoskeleton |
| CC | IEA | GO:0030027 | lamellipodium |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | IPI | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: BCAR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCAR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3967 | miR-509-3p alteration of YAP1-ECM axis |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | endothelinpathway | Endothelins |
| pid | epha2_fwdpathway | EPHA2 forward signaling |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | igf1_pathway | IGF1 pathway |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
| pid | integrin_a9b1_pathway | Alpha9 beta1 integrin signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | cell2cellpathway | cell to cell adhesion signaling |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849471 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD64 | Parbendazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCAR1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.