CD63
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD63 molecule | MIM:155740 | Ensembl:ENSG00000135404 | HGNC:HGNC:1692 | PA26231 | 12q13.2 |
GO terms in CD63
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| BP | IMP | GO:0002092 | positive regulation of receptor internalization |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | IBA | GO:0007155 | cell adhesion |
| BP | IMP | GO:0007160 | cell-matrix adhesion |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IEA | GO:0015031 | protein transport |
| BP | IBA | GO:0016477 | cell migration |
| BP | IMP | GO:0016477 | cell migration |
| BP | IDA | GO:0034613 | cellular protein localization |
| BP | IMP | GO:0035646 | endosome to melanosome transport |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0045807 | positive regulation of endocytosis |
| BP | IMP | GO:0048757 | pigment granule maturation |
| BP | IMP | GO:1900746 | regulation of vascular endothelial growth factor signaling pathway |
| BP | IDA | GO:1901379 | regulation of potassium ion transmembrane transport |
| BP | IMP | GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| CC | IDA | GO:0005615 | extracellular space |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005765 | lysosomal membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0010008 | endosome membrane |
| CC | TAS | GO:0031088 | platelet dense granule membrane |
| CC | IDA | GO:0031226 | intrinsic component of plasma membrane |
| CC | IDA | GO:0031902 | late endosome membrane |
| CC | IDA | GO:0031904 | endosome lumen |
| CC | HDA | GO:0032585 | multivesicular body membrane |
| CC | IDA | GO:0032585 | multivesicular body membrane |
| CC | TAS | GO:0035577 | azurophil granule membrane |
| CC | IEA | GO:0042470 | melanosome |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0097487 | multivesicular body, internal vesicle |
Gene expression in normal tissue: CD63
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD63
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| kegg | hsa04142 | Lysosome - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD63
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