RAB11FIP3
Summary: Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAB11 family interacting protein 3 | MIM:608738 | Ensembl:ENSG00000090565 | HGNC:HGNC:17224 | PA134950896 | 16p13.3 |
Gene Categories:
CELL SURFACEGO terms in RAB11FIP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000910 | cytokinesis |
| BP | TAS | GO:0016192 | vesicle-mediated transport |
| BP | IBA | GO:0032456 | endocytic recycling |
| BP | IDA | GO:0032456 | endocytic recycling |
| BP | IMP | GO:0032465 | regulation of cytokinesis |
| BP | IDA | GO:0070164 | negative regulation of adiponectin secretion |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005768 | endosome |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0030139 | endocytic vesicle |
| CC | IBA | GO:0030496 | midbody |
| CC | IDA | GO:0030496 | midbody |
| CC | IBA | GO:0032154 | cleavage furrow |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0045171 | intercellular bridge |
| CC | IDA | GO:0055037 | recycling endosome |
| CC | IBA | GO:0055038 | recycling endosome membrane |
| CC | IEA | GO:0055038 | recycling endosome membrane |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017137 | Rab GTPase binding |
| MF | IPI | GO:0017137 | Rab GTPase binding |
| MF | NAS | GO:0017137 | Rab GTPase binding |
| MF | IBA | GO:0030306 | ADP-ribosylation factor binding |
| MF | IPI | GO:0030306 | ADP-ribosylation factor binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0051959 | dynein light intermediate chain binding |
Gene expression in normal tissue: RAB11FIP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAB11FIP3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620916 | VxPx cargo-targeting to cilium |
| reactome | R-HSA-5620920 | Cargo trafficking to the periciliary membrane |
| pid | arf6downstreampathway | Arf6 downstream pathway |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAB11FIP3
CLASSFICATION
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