HDAC9
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| histone deacetylase 9 | MIM:606543 | Ensembl:ENSG00000048052 | HGNC:HGNC:14065 | PA38377 | 7p21.1 |
GO terms in HDAC9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005080 | protein kinase C binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) |
| MF | IDA | GO:0033558 | protein deacetylase activity |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0070491 | repressing transcription factor binding |
| MF | IPI | GO:0070491 | repressing transcription factor binding |
| MF | ISS | GO:0070491 | repressing transcription factor binding |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001975 | response to amphetamine |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | ISS | GO:0007507 | heart development |
| BP | IDA | GO:0016575 | histone deacetylation |
| BP | IEA | GO:0030182 | neuron differentiation |
| BP | TAS | GO:0030183 | B cell differentiation |
| BP | IDA | GO:0032869 | cellular response to insulin stimulus |
| BP | IDA | GO:0034983 | peptidyl-lysine deacetylation |
| BP | TAS | GO:0042113 | B cell activation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0048742 | regulation of skeletal muscle fiber development |
| BP | ISS | GO:0051153 | regulation of striated muscle cell differentiation |
| BP | IDA | GO:0070932 | histone H3 deacetylation |
| BP | IDA | GO:0070933 | histone H4 deacetylation |
| BP | IMP | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| CC | TAS | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | ISS | GO:0035097 | histone methyltransferase complex |
Gene expression in normal tissue: HDAC9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HDAC9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | mitrpathway | signal dependent regulation of myogenesis by corepressor mitr |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | ranbp2pathway | sumoylation by ranbp2 regulates transcriptional repression |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3996 | Ethanol effects on histone modifications |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| pharmgkb | PA165959313 | Valproic Acid Pathway, Pharmacodynamics |
| pharmgkb | PA165964473 | Pathway_PA165964473 |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HDAC9
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