HDAC9


Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:606543
PHARMGKB IDPA38377
Map Location7p21.1

GO terms in HDAC9


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0003714 transcription corepressor activity
MF IDA GO:0004407 histone deacetylase activity
MF IPI GO:0005080 protein kinase C binding
MF IPI GO:0005515 protein binding
MF IDA GO:0008134 transcription factor binding
MF IPI GO:0008134 transcription factor binding
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Gene expression in normal tissue: HDAC9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HDAC9


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Database
Pathway ID
Pathway Des.
biocarta mitrpathway signal dependent regulation of myogenesis by corepressor mitr
biocarta nfatpathway nfat and hypertrophy of the heart
biocarta ranbp2pathway sumoylation by ranbp2 regulates transcriptional repression
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1643685 Disease
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD232 FTI-277 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HDAC9

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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