RIPOR2

Summary: This gene encodes an atypical inhibitor of the small G protein RhoA. Inhibition of RhoA activity by the encoded protein mediates myoblast fusion and polarization of T cells and neutrophils. The encoded protein is a component of hair cell stereocilia that is essential for hearing. A splice site mutation in this gene results in hearing loss in human patients. [provided by RefSeq, Sep 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRHO family interacting cell polarization regulator 2
OMIM IDMIM:611410
Ensembl IDEnsembl:ENSG00000111913
HGNC IDHGNC:HGNC:13872
PHARMGKB IDPA162387677
Map Location6p22.3

GO terms in RIPOR2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IDA GO:0071889 14-3-3 protein binding
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005856 cytoskeleton
CC IEA GO:0016324 apical plasma membrane
CC IDA GO:0030175 filopodium
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Gene expression in normal tissue: RIPOR2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Protein stability and degradation1

Pathways in RIPOR2


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIPOR2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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