RIPOR2
Summary: This gene encodes an atypical inhibitor of the small G protein RhoA. Inhibition of RhoA activity by the encoded protein mediates myoblast fusion and polarization of T cells and neutrophils. The encoded protein is a component of hair cell stereocilia that is essential for hearing. A splice site mutation in this gene results in hearing loss in human patients. [provided by RefSeq, Sep 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RHO family interacting cell polarization regulator 2 | MIM:611410 | Ensembl:ENSG00000111913 | HGNC:HGNC:13872 | PA162387677 | 6p22.3 |
GO terms in RIPOR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0071889 | 14-3-3 protein binding |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0030175 | filopodium |
| CC | ISS | GO:0032420 | stereocilium |
| CC | IEA | GO:0060171 | stereocilium membrane |
| BP | IEA | GO:0006935 | chemotaxis |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IMP | GO:0007162 | negative regulation of cell adhesion |
| BP | ISS | GO:0007162 | negative regulation of cell adhesion |
| BP | IMP | GO:0007605 | sensory perception of sound |
| BP | IMP | GO:0035024 | negative regulation of Rho protein signal transduction |
| BP | ISS | GO:0035024 | negative regulation of Rho protein signal transduction |
| BP | IMP | GO:0045663 | positive regulation of myoblast differentiation |
| BP | IEA | GO:0048741 | skeletal muscle fiber development |
| BP | IMP | GO:0051491 | positive regulation of filopodium assembly |
| BP | ISS | GO:0090023 | positive regulation of neutrophil chemotaxis |
| BP | IMP | GO:1901741 | positive regulation of myoblast fusion |
| BP | IMP | GO:1903904 | negative regulation of establishment of T cell polarity |
| BP | ISS | GO:1905872 | negative regulation of protein localization to cell leading edge |
| BP | IDA | GO:1990869 | cellular response to chemokine |
| BP | ISS | GO:2000114 | regulation of establishment of cell polarity |
| BP | ISS | GO:2000391 | positive regulation of neutrophil extravasation |
| BP | IMP | GO:2000405 | negative regulation of T cell migration |
| BP | IMP | GO:2001107 | negative regulation of Rho guanyl-nucleotide exchange factor activity |
| BP | ISS | GO:2001107 | negative regulation of Rho guanyl-nucleotide exchange factor activity |
Gene expression in normal tissue: RIPOR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RIPOR2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIPOR2
CLASSFICATION
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