CD151
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD151 molecule (Raph blood group) | MIM:602243 | Ensembl:ENSG00000177697 | HGNC:HGNC:1630 | PA26189 | 11p15.5 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CD151
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| BP | NAS | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | TAS | GO:0031581 | hemidesmosome assembly |
| BP | IEA | GO:0042098 | T cell proliferation |
| BP | IDA | GO:0044319 | wound healing, spreading of cells |
| BP | IMP | GO:0044319 | wound healing, spreading of cells |
| BP | IDA | GO:0045807 | positive regulation of endocytosis |
| BP | IMP | GO:0045807 | positive regulation of endocytosis |
| CC | IDA | GO:0005604 | basement membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009986 | cell surface |
| CC | TAS | GO:0016020 | membrane |
Gene expression in normal tissue: CD151
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD151
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures |
| reactome | R-HSA-446107 | Type I hemidesmosome assembly |
| reactome | R-HSA-446728 | Cell junction organization |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD151
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