RNF40
Summary: The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ring finger protein 40 | MIM:607700 | Ensembl:ENSG00000103549 | HGNC:HGNC:16867 | PA34440 | 16p11.2 |
Gene Categories:
HISTONE MODIFICATIONGO terms in RNF40
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017075 | syntaxin-1 binding |
| MF | IEA | GO:0031624 | ubiquitin conjugating enzyme binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0000151 | ubiquitin ligase complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0019898 | extrinsic component of membrane |
| CC | IDA | GO:0033503 | HULC complex |
| CC | ISS | GO:0043005 | neuron projection |
| CC | IEA | GO:0043679 | axon terminus |
| BP | ISS | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0007346 | regulation of mitotic cell cycle |
| BP | IDA | GO:0010390 | histone monoubiquitination |
| BP | TAS | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0033523 | histone H2B ubiquitination |
| BP | IEA | GO:0043434 | response to peptide hormone |
| BP | IMP | GO:1900364 | negative regulation of mRNA polyadenylation |
| BP | IEA | GO:1901800 | positive regulation of proteasomal protein catabolic process |
| BP | IEA | GO:1902916 | positive regulation of protein polyubiquitination |
| BP | IMP | GO:2001168 | positive regulation of histone H2B ubiquitination |
Gene expression in normal tissue: RNF40
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNF40
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8852135 | Protein ubiquitination |
| reactome | R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNF40
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