DNAJC6
Summary: DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DnaJ heat shock protein family (Hsp40) member C6 | MIM:608375 | Ensembl:ENSG00000116675 | HGNC:HGNC:15469 | PA27423 | 1p31.3 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in DNAJC6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | IBA | GO:0030276 | clathrin binding |
| BP | IBA | GO:0006898 | receptor-mediated endocytosis |
| BP | IBA | GO:0016191 | synaptic vesicle uncoating |
| BP | ISS | GO:0016191 | synaptic vesicle uncoating |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IBA | GO:0072318 | clathrin coat disassembly |
| BP | IBA | GO:0072583 | clathrin-dependent endocytosis |
| BP | IEA | GO:2000369 | regulation of clathrin-dependent endocytosis |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IBA | GO:0031982 | vesicle |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: DNAJC6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DNAJC6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-432720 | Lysosome Vesicle Biogenesis |
| reactome | R-HSA-432722 | Golgi Associated Vesicle Biogenesis |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DNAJC6
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.