TRIM14
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606556 Ensembl IDEnsembl:ENSG00000106785 HGNC IDHGNC:HGNC:16283 PHARMGKB IDPA38113 Map Location9q22.33 | |||||
GO terms in TRIM14
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IEA | GO:0008270 | zinc ion binding |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| BP | IDA | GO:0032897 | negative regulation of viral transcription |
| BP | IDA | GO:0045087 | innate immune response |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
Gene expression in normal tissue: TRIM14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIM14
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIM14
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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