TRIM14
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tripartite motif containing 14 | MIM:606556 | Ensembl:ENSG00000106785 | HGNC:HGNC:16283 | PA38113 | 9q22.33 |
GO terms in TRIM14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IEA | GO:0008270 | zinc ion binding |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| BP | IDA | GO:0032897 | negative regulation of viral transcription |
| BP | IDA | GO:0045087 | innate immune response |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
Gene expression in normal tissue: TRIM14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIM14
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIM14
CLASSFICATION
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