GAB2
Summary: This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606203 Ensembl IDEnsembl:ENSG00000033327 HGNC IDHGNC:HGNC:14458 PHARMGKB IDPA28478 Map Location11q14.1 | |||||
GO terms in GAB2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| MF | ISS | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding |
| BP | IEA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | TAS | GO:0007411 | axon guidance |
Gene expression in normal tissue: GAB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAB2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GAB2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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