Summary: This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009].

GRB2 associated binding protein 2MIM:606203Ensembl:ENSG00000033327HGNC:HGNC:14458PA2847811q14.1

GO terms in GAB2

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005068transmembrane receptor protein tyrosine kinase adaptor activity
MFIPIGO:0005515protein binding
MFISSGO:0005547phosphatidylinositol-3,4,5-trisphosphate binding
MFISSGO:0043325phosphatidylinositol-3,4-bisphosphate binding
BPIEAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPTASGO:0007411axon guidance
BPIDAGO:0008284positive regulation of cell proliferation
BPTASGO:0019221cytokine-mediated signaling pathway
BPIMPGO:0030316osteoclast differentiation
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPISSGO:0043306positive regulation of mast cell degranulation
BPISSGO:0048015phosphatidylinositol-mediated signaling
CCIDAGO:0005886plasma membrane

Gene expression in normal tissue: GAB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GAB2

DatabasePathway IDPathway Des.
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-1839117Signaling by cytosolic FGFR1 fusion mutants
reactomeR-HSA-1839124FGFR1 mutant receptor activation
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-8853659RET signaling
reactomeR-HSA-8983432Interleukin-15 signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-912526Interleukin receptor SHC signaling
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidgmcsf_pathwayGMCSF-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidil3_pathwayIL3-mediated signaling events
pidil6_7pathwayIL6-mediated signaling events
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidshp2_pathwaySHP2 signaling
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
wikipathwaysWP3676BDNF-TrkB Signaling
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GAB2