MAGI2
Summary: The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| membrane associated guanylate kinase, WW and PDZ domain containing 2 | MIM:606382 | Ensembl:ENSG00000187391 | HGNC:HGNC:18957 | PA142671484 | 7q21.11 |
GO terms in MAGI2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0002092 | positive regulation of receptor internalization |
| BP | NAS | GO:0003402 | planar cell polarity pathway involved in axis elongation |
| BP | ISS | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0010976 | positive regulation of neuron projection development |
| BP | ISS | GO:0030336 | negative regulation of cell migration |
| BP | IDA | GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
| BP | ISS | GO:0032926 | negative regulation of activin receptor signaling pathway |
| BP | ISS | GO:0038180 | nerve growth factor signaling pathway |
| BP | ISS | GO:0043113 | receptor clustering |
| BP | ISS | GO:0051291 | protein heterooligomerization |
| BP | IDA | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | ISS | GO:0060395 | SMAD protein signal transduction |
| BP | ISS | GO:0071850 | mitotic cell cycle arrest |
| BP | ISS | GO:0072015 | glomerular visceral epithelial cell development |
| BP | IEA | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly |
| BP | ISS | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | IEA | GO:2000809 | positive regulation of synaptic vesicle clustering |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005770 | late endosome |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005923 | bicellular tight junction |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | ISS | GO:0030425 | dendrite |
| CC | ISS | GO:0032991 | protein-containing complex |
| CC | ISS | GO:0036057 | slit diaphragm |
| CC | ISS | GO:0045202 | synapse |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019902 | phosphatase binding |
| MF | IDA | GO:0030159 | receptor signaling complex scaffold activity |
| MF | IPI | GO:0031697 | beta-1 adrenergic receptor binding |
| MF | ISS | GO:0046332 | SMAD binding |
| MF | ISS | GO:0070699 | type II activin receptor binding |
Gene expression in normal tissue: MAGI2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAGI2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-373753 | Nephrin family interactions |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAGI2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.