MAGI2
Summary: The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606382 Ensembl IDEnsembl:ENSG00000187391 HGNC IDHGNC:HGNC:18957 PHARMGKB IDPA142671484 Map Location7q21.11 | |||||
GO terms in MAGI2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0002092 | positive regulation of receptor internalization |
| BP | NAS | GO:0003402 | planar cell polarity pathway involved in axis elongation |
| BP | ISS | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0010976 | positive regulation of neuron projection development |
| BP | ISS | GO:0030336 | negative regulation of cell migration |
| BP | IDA | GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
Gene expression in normal tissue: MAGI2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAGI2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-373753 | Nephrin family interactions |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAGI2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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