CDC5L


Summary: The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602868
PHARMGKB IDPA26270
Map Location6p21.1

GO terms in CDC5L


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IEA GO:0001222 transcription corepressor binding
MF IDA GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Gene expression in normal tissue: CDC5L

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDC5L


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Database
Pathway ID
Pathway Des.
kegg hsa03040 Spliceosome - Homo sapiens (human)
reactome R-HSA-72163 mRNA Splicing - Major Pathway
reactome R-HSA-72172 mRNA Splicing
reactome R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
reactome R-HSA-8953854 Metabolism of RNA
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD367 Ro 28-1675 3
iGMDRD872 BRD7137 3
iGMDRD888 Compound 44 3
iGMDRD329 Merck60 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDC5L

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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