CDC5L
Summary: The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell division cycle 5 like | MIM:602868 | Ensembl:ENSG00000096401 | HGNC:HGNC:1743 | PA26270 | 6p21.1 |
GO terms in CDC5L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001222 | transcription corepressor binding |
| MF | IDA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | NAS | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008157 | protein phosphatase 1 binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0043522 | leucine zipper domain binding |
| MF | IDA | GO:0071987 | WD40-repeat domain binding |
| BP | IEA | GO:0000278 | mitotic cell cycle |
| BP | IC | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IDA | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0071352 | cellular response to interleukin-2 |
| BP | IMP | GO:0072422 | signal transduction involved in DNA damage checkpoint |
| BP | IEA | GO:1904568 | cellular response to wortmannin |
| BP | IEA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | IEA | GO:1990646 | cellular response to prolactin |
| CC | IDA | GO:0000974 | Prp19 complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005662 | DNA replication factor A complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0071007 | U2-type catalytic step 2 spliceosome |
| CC | IDA | GO:0071013 | catalytic step 2 spliceosome |
Gene expression in normal tissue: CDC5L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC5L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03040 | Spliceosome - Homo sapiens (human) |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD231 | Importazole | 4 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD387 | CHIR-99021 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC5L
CLASSFICATION
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