EXOG
Summary: This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| exo/endonuclease G | MIM:604051 | Ensembl:ENSG00000157036 | HGNC:HGNC:3347 | PA27784 | 3p22.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in EXOG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IBA | GO:0004518 | nuclease activity |
| MF | IDA | GO:0004519 | endonuclease activity |
| MF | NAS | GO:0004519 | endonuclease activity |
| MF | IDA | GO:0008409 | 5'-3' exonuclease activity |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005743 | mitochondrial inner membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | IBA | GO:0000737 | DNA catabolic process, endonucleolytic |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
Gene expression in normal tissue: EXOG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EXOG
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EXOG
CLASSFICATION
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