EXOG
Summary: This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604051 Ensembl IDEnsembl:ENSG00000157036 HGNC IDHGNC:HGNC:3347 PHARMGKB IDPA27784 Map Location3p22.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in EXOG
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IBA | GO:0004518 | nuclease activity |
| MF | IDA | GO:0004519 | endonuclease activity |
| MF | NAS | GO:0004519 | endonuclease activity |
| MF | IDA | GO:0008409 | 5'-3' exonuclease activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: EXOG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EXOG
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EXOG
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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