ABCB1


Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ATP binding cassette subfamily B member 1MIM:171050Ensembl:ENSG00000085563HGNC:HGNC:40PA2677q21.12

GO terms in ABCB1


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005215transporter activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0008559xenobiotic transmembrane transporting ATPase activity
MFTASGO:0042626ATPase activity, coupled to transmembrane movement of substances
MFIDAGO:0090554phosphatidylcholine-translocating ATPase activity
MFIDAGO:0090555phosphatidylethanolamine-translocating ATPase activity
MFIDAGO:0099038ceramide-translocating ATPase activity
BPIDAGO:0000086G2/M transition of mitotic cell cycle
BPIEAGO:0006855drug transmembrane transport
BPTASGO:0042493response to drug
BPIEAGO:0042908xenobiotic transport
BPIDAGO:0045332phospholipid translocation
BPIMPGO:0047484regulation of response to osmotic stress
BPTASGO:0055085transmembrane transport
BPIMPGO:0072089stem cell proliferation
BPIDAGO:0099040ceramide translocation
BPIMPGO:1901529positive regulation of anion channel activity
BPIMPGO:2001225regulation of chloride transport
CCTASGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCTASGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0016324apical plasma membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: ABCB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ABCB1


DatabasePathway IDPathway Des.
pidhif1_tfpathwayHIF-1-alpha transcription factor network
kegghsa02010ABC transporters - Homo sapiens (human)
kegghsa04976Bile secretion - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
pharmgkbPA145011108Statin Pathway - Generalized, Pharmacokinetics
pharmgkbPA145011109Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
pharmgkbPA145011110Pravastatin Pathway, Pharmacokinetics
pharmgkbPA145011113Warfarin Pathway, Pharmacokinetics
pharmgkbPA146123006Codeine and Morphine Pathway, Pharmacokinetics
pharmgkbPA150981002Vinka Alkaloid Pathway, Pharmacokinetics
pharmgkbPA152325160Gefitinib Pathway, Pharmacokinetics
pharmgkbPA152530846Proton Pump Inhibitor Pathway, Pharmacokinetics
pharmgkbPA154424674Clopidogrel Pathway, Pharmacokinetics
pharmgkbPA154426155Taxane Pathway, Pharmacokinetics
pharmgkbPA154426903Erlotinib Pathway, Pharmacokinetics
pharmgkbPA164713427Imatinib Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkbPA164713429Citalopram Pathway, Pharmacokinetics
pharmgkbPA165292163Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
pharmgkbPA165292177Doxorubicin Pathway, Pharmacokinetics
pharmgkbPA165816270Methotrexate Pathway (Brain Cell), Pharmacokinetics
pharmgkbPA165816349Methotrexate Pathway, Pharmacokinetics
pharmgkbPA165859361Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkbPA165860384Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkbPA165964832Mycophenolic acid Pathway, Pharmacokinetics
pharmgkbPA165986114Tacrolimus/Cyclosporine Pathway, Pharmacokinetics
pharmgkbPA165986194Pathway_PA165986194 -need delete
pharmgkbPA165986279Acetaminophen Pathway, Pharmacokinetics
pharmgkbPA2001Irinotecan Pathway, Pharmacokinetics
pharmgkbPA2025Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkbPA2029Irinotecan Pathway, Pharmacodynamics
pharmgkbPA2031Statin Pathway, Pharmacodynamics
smpdbSMP00260Clopidogrel Action Pathway
smpdbSMP00433Irinotecan Action Pathway
smpdbSMP00434Paclitaxel Action Pathway
smpdbSMP00435Docetaxel Action Pathway
smpdbSMP00436Vinblastine Action Pathway
smpdbSMP00437Vincristine Action Pathway
smpdbSMP00438Vindesine Action Pathway
smpdbSMP00439Vinorelbine Action Pathway
smpdbSMP00442Etoposide Action Pathway
smpdbSMP00472Erlotinib Action Pathway
smpdbSMP00600Irinotecan Metabolism Pathway
smpdbSMP00601Etoposide Metabolism Pathway
smpdbSMP00610Clopidogrel Metabolism Pathway
smpdbSMP00636Venlafaxine Metabolism Pathway
smpdbSMP00640Acetaminophen Metabolism Pathway
smpdbSMP00649Lamivudine Metabolism Pathway
smpdbSMP00650Doxorubicin Metabolism Pathway
smpdbSMP00652Mycophenolic Acid Metabolism Pathway
wikipathwaysWP1604Codeine and Morphine Metabolism
wikipathwaysWP2289Drug Induction of Bile Acid Pathway
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2875Constitutive Androstane Receptor Pathway
wikipathwaysWP2876Pregnane X Receptor pathway
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP299Nuclear Receptors in Lipid Metabolism and Toxicity
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
wikipathwaysWP3672LncRNA-mediated mechanisms of therapeutic resistance
wikipathwaysWP4010Liver steatosis AOP
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-2161517Abacavir transmembrane transport
reactomeR-HSA-2161522Abacavir transport and metabolism
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-382556ABC-family proteins mediated transport
biocartamrppathwaymulti-drug resistance factors
biocartap53hypoxiapathwayhypoxia and p53 in the cardiovascular system

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD288Carboplatin1
iGMDRD328AR-421
iGMDRD160Cis-Platin1
iGMDRD30917AAG2
iGMDRD68Paclitaxel4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABCB1

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