ABCG2
Summary: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATP binding cassette subfamily G member 2 (Junior blood group) | MIM:603756 | Ensembl:ENSG00000118777 | HGNC:HGNC:74 | PA390 | 4q22.1 |
GO terms in ABCG2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005215 | transporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0008559 | xenobiotic transmembrane transporting ATPase activity |
| MF | TAS | GO:0015232 | heme transporter activity |
| MF | IBA | GO:0015238 | drug transmembrane transporter activity |
| MF | IBA | GO:0017127 | cholesterol transporter activity |
| MF | IBA | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | TAS | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| BP | IEA | GO:0006855 | drug transmembrane transport |
| BP | TAS | GO:0006879 | cellular iron ion homeostasis |
| BP | IEA | GO:0015886 | heme transport |
| BP | IBA | GO:0033344 | cholesterol efflux |
| BP | TAS | GO:0042493 | response to drug |
| BP | IEA | GO:0042908 | xenobiotic transport |
| BP | IMP | GO:0046415 | urate metabolic process |
| BP | IBA | GO:0055085 | transmembrane transport |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0031966 | mitochondrial membrane |
| CC | IBA | GO:0043235 | receptor complex |
Gene expression in normal tissue: ABCG2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCG2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA145011108 | Statin Pathway - Generalized, Pharmacokinetics |
| pharmgkb | PA145011110 | Pravastatin Pathway, Pharmacokinetics |
| pharmgkb | PA150642262 | Platinum Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA150653776 | Fluoropyrimidine Pathway, Pharmacokinetics |
| pharmgkb | PA152325160 | Gefitinib Pathway, Pharmacokinetics |
| pharmgkb | PA154426155 | Taxane Pathway, Pharmacokinetics |
| pharmgkb | PA154426903 | Erlotinib Pathway, Pharmacokinetics |
| pharmgkb | PA164713427 | Imatinib Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165292163 | Doxorubicin Pathway (Cancer Cell), Pharmacodynamics |
| pharmgkb | PA165292177 | Doxorubicin Pathway, Pharmacokinetics |
| pharmgkb | PA165816270 | Methotrexate Pathway (Brain Cell), Pharmacokinetics |
| pharmgkb | PA165816349 | Methotrexate Pathway, Pharmacokinetics |
| pharmgkb | PA165859361 | Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165860384 | Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics |
| pharmgkb | PA165986194 | Pathway_PA165986194 -need delete |
| pharmgkb | PA165986279 | Acetaminophen Pathway, Pharmacokinetics |
| pharmgkb | PA166114721 | Uricosurics Pathway, Pharmacodynamics |
| pharmgkb | PA2001 | Irinotecan Pathway, Pharmacokinetics |
| pharmgkb | PA2029 | Irinotecan Pathway, Pharmacodynamics |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| kegg | hsa02010 | ABC transporters - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| smpdb | SMP00433 | Irinotecan Action Pathway |
| smpdb | SMP00434 | Paclitaxel Action Pathway |
| smpdb | SMP00435 | Docetaxel Action Pathway |
| smpdb | SMP00472 | Erlotinib Action Pathway |
| smpdb | SMP00600 | Irinotecan Metabolism Pathway |
| smpdb | SMP00640 | Acetaminophen Metabolism Pathway |
| smpdb | SMP00649 | Lamivudine Metabolism Pathway |
| smpdb | SMP00650 | Doxorubicin Metabolism Pathway |
| smpdb | SMP00652 | Mycophenolic Acid Metabolism Pathway |
| wikipathways | WP1601 | Fluoropyrimidine Activity |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP229 | Irinotecan Pathway |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP3640 | Imatinib and Chronic Myeloid Leukemia |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-2161517 | Abacavir transmembrane transport |
| reactome | R-HSA-2161522 | Abacavir transport and metabolism |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-917937 | Iron uptake and transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCG2
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