Summary: The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein is a member of the White subfamily and plays an important role in cellular cholesterol homeostasis. This protein functions as either a homodimer or as a heterodimer with another ABC subfamily protein such as ABCG1. [provided by RefSeq, Jan 2017].

ATP binding cassette subfamily G member 4MIM:607784Ensembl:ENSG00000172350HGNC:HGNC:13884PA2441011q23.3

GO terms in ABCG4

Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
BPIBAGO:0030301cholesterol transport
BPIBAGO:0033344cholesterol efflux
BPTASGO:0033344cholesterol efflux
BPIBAGO:0055085transmembrane transport
BPTASGO:0055085transmembrane transport
BPIEAGO:1990830cellular response to leukemia inhibitory factor
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0017127cholesterol transporter activity
MFTASGO:0017127cholesterol transporter activity
MFIBAGO:0034041sterol-transporting ATPase activity
MFIBAGO:0042626ATPase activity, coupled to transmembrane movement of substances
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0046982protein heterodimerization activity

Gene expression in normal tissue: ABCG4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ABCG4

DatabasePathway IDPathway Des.
reactomeR-HSA-1369062ABC transporters in lipid homeostasis
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-382556ABC-family proteins mediated transport
kegghsa02010ABC transporters - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABCG4