ABCG4
Summary: The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein is a member of the White subfamily and plays an important role in cellular cholesterol homeostasis. This protein functions as either a homodimer or as a heterodimer with another ABC subfamily protein such as ABCG1. [provided by RefSeq, Jan 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ATP binding cassette subfamily G member 4 | MIM:607784 | Ensembl:ENSG00000172350 | HGNC:HGNC:13884 | PA24410 | 11q23.3 |
GO terms in ABCG4
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
BP | IBA | GO:0030301 | cholesterol transport |
BP | IBA | GO:0033344 | cholesterol efflux |
BP | TAS | GO:0033344 | cholesterol efflux |
BP | IBA | GO:0055085 | transmembrane transport |
BP | TAS | GO:0055085 | transmembrane transport |
BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
MF | IBA | GO:0017127 | cholesterol transporter activity |
MF | TAS | GO:0017127 | cholesterol transporter activity |
MF | IBA | GO:0034041 | sterol-transporting ATPase activity |
MF | IBA | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
MF | IDA | GO:0042803 | protein homodimerization activity |
MF | IPI | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: ABCG4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCG4
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1369062 | ABC transporters in lipid homeostasis |
reactome | R-HSA-382551 | Transport of small molecules |
reactome | R-HSA-382556 | ABC-family proteins mediated transport |
kegg | hsa02010 | ABC transporters - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCG4