ACLY
Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ATP citrate lyase | MIM:108728 | Ensembl:ENSG00000131473 | HGNC:HGNC:115 | PA24441 | 17q21.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ACLY
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0003878 | ATP citrate synthase activity |
MF | IDA | GO:0003878 | ATP citrate synthase activity |
MF | TAS | GO:0003878 | ATP citrate synthase activity |
MF | IPI | GO:0005515 | protein binding |
MF | TAS | GO:0005524 | ATP binding |
MF | IEA | GO:0046872 | metal ion binding |
MF | IEA | GO:0048037 | cofactor binding |
CC | TAS | GO:0005576 | extracellular region |
CC | IDA | GO:0005654 | nucleoplasm |
CC | IBA | GO:0005829 | cytosol |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0005886 | plasma membrane |
CC | IBA | GO:0009346 | citrate lyase complex |
CC | HDA | GO:0016020 | membrane |
CC | TAS | GO:0035578 | azurophil granule lumen |
CC | HDA | GO:0070062 | extracellular exosome |
CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
BP | IBA | GO:0006085 | acetyl-CoA biosynthetic process |
BP | IDA | GO:0006085 | acetyl-CoA biosynthetic process |
BP | IDA | GO:0006101 | citrate metabolic process |
BP | IDA | GO:0006107 | oxaloacetate metabolic process |
BP | IBA | GO:0006633 | fatty acid biosynthetic process |
BP | TAS | GO:0006695 | cholesterol biosynthetic process |
BP | IDA | GO:0008610 | lipid biosynthetic process |
BP | TAS | GO:0015936 | coenzyme A metabolic process |
BP | TAS | GO:0031325 | positive regulation of cellular metabolic process |
BP | TAS | GO:0043312 | neutrophil degranulation |
BP | TAS | GO:0046949 | fatty-acyl-CoA biosynthetic process |
Gene expression in normal tissue: ACLY
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACLY
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
wikipathways | WP2453 | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
wikipathways | WP357 | Fatty Acid Biosynthesis |
wikipathways | WP3925 | Amino Acid metabolism |
wikipathways | WP3965 | Lipid Metabolism Pathway |
wikipathways | WP4010 | Liver steatosis AOP |
wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
smpdb | SMP00466 | Transfer of Acetyl Groups into Mitochondria |
smpdb | SMP02298 | Glutaminolysis and Cancer |
humancyc | PWY-5172 | acetyl-CoA biosynthesis from citrate |
netpath | Pathway_TCR | TCR |
kegg | hsa00020 | Citrate cycle (TCA cycle) - Homo sapiens (human) |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-163685 | Integration of energy metabolism |
reactome | R-HSA-163765 | ChREBP activates metabolic gene expression |
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-556833 | Metabolism of lipids |
reactome | R-HSA-6798695 | Neutrophil degranulation |
reactome | R-HSA-75105 | Fatty acyl-CoA biosynthesis |
reactome | R-HSA-8978868 | Fatty acid metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACLY